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Chiral inversion of (R)-(-)-fenoprofen in guinea-pigs pretreated with clofibrate
(Springer, 2002-06)
The influence of clofibrate on the stereoconversion of fenoprofen (FPF) was studied in guinea pigs. This hypolipidaemic agent has been related to some biochemical changes in the liver leading to an increase in the chiral ...
Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease
(Medwell Online, 2006-12)
The 2-arylpropionic acids (2-APA) or profens, is a family of Non-Steroidal Anti-Inflamatory Drug (NSAIDS), widely used in human and veterinary medicine for the treatment of the arthritis, musculoskeletal disorders and ...
Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies
(Taylor & Francis Ltd, 2011)
Chiral inversion of R(-) fenoprofen and ketoprofen enantiomers in cats
(Wiley Blackwell Publishing, Inc, 2000-10)
The chiral inversion process is a characteristic metabolic pathway for different aryl-2-propionic acids or profens. Important variations have been observed between these individual compounds as well as between animal ...
Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug: Promising Insights in the Treatment of Chronic Inflammatory Diseases
(Hindawi Publishing Corporation, 2014-07)
Analgesic and ulcerogenic properties have been studied for the copper(II) coordination complex of the nonsteroidal anti-inflammatory drug Fenoprofen and imidazole [Cu(fen)2(im)2] (Cu: copper(II) ion; fen: fenoprofenate ...
Tetra-kis[-2-(3-phenoxy-phen-yl)propionato-κ2 O:O′]bis-[(dimethyl-formamide-O)copper(II)]
(Wiley Blackwell Publishing, Inc, 2008-12)
The title compound, [Cu2(C15H13O3)4(C3H7NO)2], is formed by the chelate coordination of four racemic fenoprofenate (fenoprofenate is 2,3-phenoxyphenyl propionate) anions and two dimethyl-formamide mol-ecules to two copper(II) ...
Determinação de fármacos nos rios Atuba, Belém e Palmital
(Universidade Tecnológica Federal do ParanáCuritibaBrasilCurso de Bacharelado em QuímicaUTFPR, 2015-11-20)
A wide variety of contaminants, including drugs, are continuously released into the aquatic environment. Untreated domestic wastewater and effluents from sewage treatment plants are well known to be a possible source of ...
Analysis of ibuprofen enantiomers in rat plasma by liquid chromatography with tandem mass spectrometry
(Wiley-Blackwell, 2014-04-01)
A sensitive and selective method for the analysis of ibuprofen enantiomers by LC-MS/MS was developed and validated for the purpose of application in pharmacokinetic studies in small experimental animals. Aliquots of 200 L ...
Avaliação de efeitos biológicos de antiinflamatórios derivados do ácido propiônico através de modelos experimentais em nível molecular e celular
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em Ciências da SaúdeCiências da Saúde, 2010-08-31)
Derivatives of propionic acid NSAIDs are irreversible inhibitors of cyclooxygenase enzyme widely used. The aim of this study was to evaluate, through different experimental models, biological effects of derivatives of ...