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Modelling and optimization of the cephalosporin C production bioprocess in a fed-batch bioreactor with invert sugar as substrate
(Elsevier B.V., 1999-08-01)
Cephalosporin C production process optimization was studied based on four experiments carried out in an agitated and aerated tank fermenter operated as a fed-batch reactor. The microorganism Cephalosporium acremonium ATCC ...
Modelling and optimization of the cephalosporin C production bioprocess in a fed-batch bioreactor with invert sugar as substrate
(Elsevier B.V., 1999-08-01)
Cephalosporin C production process optimization was studied based on four experiments carried out in an agitated and aerated tank fermenter operated as a fed-batch reactor. The microorganism Cephalosporium acremonium ATCC ...
Sufficient conditions for state observability in multi-substrate bioprocesses with additive growth dynamics
(Institute of Electrical and Electronics Engineers, 2014-07)
The distinguishability of the non-measured states is relevant for the design and implementation of state observers. The aim of this study is to examine the observability of a fed-batch multi-substrate process with additive ...
Tracking Control of Optimal Profiles in a Nonlinear Fed-Batch Bioprocess under Parametric Uncertainty and Process Disturbances
(American Chemical Society, 2018-07)
The problem of optimal profiles tracking control under uncertainties for a nonlinear fed-batch bioprocess is addressed in this paper. Based on the results reported by Pantano et al. [ Ind. Eng. Chem. Res. 2017, 56, 6043], ...
The dead core model applied to beads with immobilized cells in a fed-batch cephalosporin C production bioprocess
(Elsevier B.V., 2001-01-01)
Viable cells immobilized in inert supports are currently studied for a wide range of bioprocesses. The intrinsic advantages of such systems over suspended cultures incite new research, including studies on fundamental ...
The dead core model applied to beads with immobilized cells in a fed-batch cephalosporin C production bioprocess
(Elsevier B.V., 2001-01-01)
Viable cells immobilized in inert supports are currently studied for a wide range of bioprocesses. The intrinsic advantages of such systems over suspended cultures incite new research, including studies on fundamental ...
Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
(Springer Verlag Berlín, 2015-06)
This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to ...