Buscar
Mostrando ítems 1-10 de 22
Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase
(Taylor & Francis, 2016-02)
Introduction: Farnesyl pyrophosphate synthase (FPPS) catalyzes the condensation of isopentenyl diphosphate with dimethylallyl diphosphate to give rise to one molecule of geranyl diphosphate, which on a further reaction ...
Caracterização da imunogenicidade de antígenos recombinantes de Trypanosoma cruzi em modelo murino
(Universidade Federal do Rio Grande do NorteBrasilUFRNFarmácia, 2020-10-29)
Chagas disease (CD) is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Numerous parasite proteins are being purified and used as antigenic candidates for the
development of vaccines in immunization ...
Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase
(Pergamon-Elsevier Science Ltd, 2005-11)
We have investigated the effect of a series of 1-amino-1,1-bisphosphonates derived from fatty acids against proliferation of the clinically more relevant form of Trypanosoma cruzi, the causative agent of American trypanosomiasis ...
Functional characterization of the xanthophyllomyces dendrorhous farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase encoding genes that are involved in the synthesis of isoprenoid precursors
(PLOS One, 2014)
The yeast Xanthophyllomyces dendrorhous synthesizes the carotenoid astaxanthin, which has applications in biotechnology
because of its antioxidant and pigmentation properties. However, wild-type strains produce too low ...
Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium falciparum
(Portland Press LtdLondonInglaterra, 2005)
New Insights into Molecular Recognition of 1,1-Bisphosphonic Acids by Farnesyl Pyrophosphate Synthase
(Elsevier, 2014-01)
As part of our project pointed at the search of new antiparasitic agents against American trypanosomiasis (Chagas disease) and toxoplasmosis a series of 2-alkylaminoethyl-1-hydroxy-1,1-bisphosphonic acids has been designed, ...