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Estudo in silico de derivados do G-CSF humano como antibacterianos
(2013-07-31)
Na tentativa de obter novas substâncias com atividade antibacteriana, o objetivo desse trabalho foi avaliar o potencial antibacteriano de quatro peptídeos sintetizados, dos quais dois possuem sequência derivada da fragmentação ...
Investigación de un fenómeno natural: ¿estudios in vivo, in vitro o in silico?
(Asociación Argentina de Osteología y Metabolismo Mineral, 2013-12)
Un tema de controversia y discusión en la investigación biomédica es la validez de la información obtenida de los experimentos realizados. Los modelos experimentales utilizados determinan el tipo de conclusiones así como ...
Modelling the Dynamics of Cow-Calf Dyadic Behavior
(Igi Global, 2018-10-01)
The dynamics of the first suckling is critical for the formation of the complex cow-calf dyad system, where interactions occur among animals and natural and anthropic environments. In this study, the system dynamics method ...
Identificação e caracterização de inibidores de Fosfolipase A2 provenientes de metabólitos secundários de plantas da Mata Atlântica listados no SUS
(Universidade Estadual Paulista (Unesp), 2022-08-01)
Neste trabalho mostramos que a integração de métodos in sílico foram cruciais para ajudar no levantamento de novos dados, revisão de fundamentos da ação de drogas e os experimentos in sílico mostraram ser valiosas ferramentas ...
Análise in silico de potenciais alvos do fator de transcrição zenk em um modelo de aprendizado vocal
(Universidade Federal do Rio Grande do NorteBrasilUFRNBacharelado em Ciências e Tecnologia - NeurociênciasInstituto do Cérebro, 2021-09-17)
Memory formation requires gene expression triggered by neuronal activity. This response
includes a series of activity-dependent genes that are thought to mediate the changes
necessary for memory consolidation and ...
In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide
(2018-09-01)
Previous studies have shown that cowpea protein positively interferes with cholesterol metabolism. In this study, we evaluated the ability of the fraction containing peptides of <3 kDa, as well as that of the Gln-Asp-Phe ...
Generation of Cry11 Variants of Bacillus thuringiensis by Heuristic Computational Modeling
(Nueva Zelanda, 2020-07-27)
Directed evolution methods mimic in vitro Darwinian evolution, inducing random mutations and selective pressure in genes to obtain proteins with enhanced characteristics. These techniques are developed using trial-and-error ...
A joint experimental, in silico and NMR studies towards the rational design of iminium-based organocatalyst derived from renewable sources
(American Chemical Society, 2015-08)
An efficient organocatalyst for iminium-ionbased asymmetric Diels−Alder (DA) reactions has beenrationally designed. The most influential structure−activityrelationships were determined experimentally, while DFTcalculations ...