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Self-declared ethnicity and genomic ancestry in prostate cancer patients from Brazil
(Funpec-editora, 2016-01-01)
Some studies of polymorphisms in prostate cancer (PCa) analyze individuals in a uniform manner, regardless of genetic ancestry. However, PCa aggressiveness differs between subjects of African descent and those of European ...
The Genetic Diversity of the Americas
(Annual Reviews, 2017)
The history of the Americas involved the encounter of millions of Native Americans, Europeans, and Africans. A variable admixture of these three continental groups has taken place throughout the continent, influenced by ...
Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
(Wiley, 2018)
OBJECTIVES: To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans. MATERIALS AND METHODS: ...
Development of a panel of genome-wide ancestry informative markers to study admixture throughout the americas
(Public Library of Science, 2012)
Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors. Complex historical factors have resulted in varying proportions of ancestral contributions between ...
Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
(National Academy of Sciences, 2015)
While South Americans are underrepresented in human genomic diversity studies, Brazil has been a classical model for population genetics studies on admixture.We present the results of the EPIGEN Brazil Initiative, the most ...
Phenotyping the ancient world: The physical appearance and ancestry of very degraded samples from a chalcolithic human remains
(Elsevier, 2017)
The genetic study of ancient samples is quite similar to a forensic critical sample analysis with an unknown origin. In both cases, it is not possible to compare the genetic information with other family members, being ...
Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos
(Sociedad Médica de Santiago, 2014)
Background: The geographical distribution of genes plays a key role in genetic epidemiology. The Chilean population has three major stem groups (Native American, European and African). Aim: To estimate the regional rate ...
Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry
(2016-06-01)
Ancestry information can be useful in investigations of diseases with a genetic or infectious background. As the Brazilian population is highly admixed physical traits tend to be poor indicators of ancestry. The assessment ...
Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance
(Springer Nature, 2018)
Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, ...
Genomic ancestry, CYP2D6, CYP2C9 and CYP2C19 among Latin-Americans
(Wiley, 2019)
We present the distribution of CYP2D6, CYP2C9 and CYP2C19 variants and predicted phenotypes in 33 native and admixed populations from Ibero-America (n>6,000) in the context of genetic ancestry (n=3,387). Continental ...