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Molecular epidemiology of hepatitis B virus mutants associated with vaccine-escape, drug-resistance and diagnosis failure
(Wiley Blackwell Publishing, Inc, 2019-05)
The massive implementation of the vaccine and antiviral agents against hepatitis B virus (HBV), targeting the envelope and viral polymerase genes, induces a selection pressure that might lead to the emergence of variants ...
Hepatitis B Virus (HBV) and S-Escape Mutants: From the Beginning until Now
(MedCrave, 2015-04)
Despite of the progress made in vaccine and antiviral therapy development, hepatitis B virus (HBV) infection remains a major health care problem. More than 240 million people are chronically infected worldwide showing ...
Variantes de escape del virus de la hepatitis BEscape Mutants of Hepatitis B Virus
(Sociedad Chilena de InfectologíaGrupo de GastrohepatologíaSantiago de Chile, Chile, 2023)
Parameters affecting cellular invasion and escape from the parasitophorous vacuole by different infective forms of Trypanosoma cruzi
(Instituto Oswaldo Cruz, Ministério da Saúde, 2003-10-01)
In this study we have examined certain aspects of the process of cell invasion and parasitophorous vacuole escape by metacyclic trypomastigotes and extracellular amastigote forms of Trypanosoma cruzi (G strain). Using Vero ...
Identifying Genes Whose Mutant Transcripts Cause Dominant Disease Traits by Potential Gain-of-Function Alleles
(2018)
Premature termination codon (PTC)-bearing transcripts are often degraded by nonsense-mediated decay (NMD) resulting in loss-of-function (LoF) alleles. However, not all PTCs result in LoF mutations, i.e., some such transcripts ...
Las variantes de SARS-CoV-2 y la llamada resistencia a las vacunasSARS-CoV-2 variants and the so-called resistance to vaccines
(Medicina (Buenos Aires), 2021-06)
Los virus ARN, excepto los retrovirus, se replican por acción de una ARN polimerasa ARN-dependiente que carece de exonucleasa correctora y, en consecuencia, en cada replicación puede cometer errores. Así se originan mutantes ...
Exogenous ketone bodies ameliorate behavioral defects associated with DAF-18/PTEN mutations
(Instituto de Biología de Rosario, 2020)
The phosphatidylinositol 3-kinase (PI3K) signaling pathway is a conserved signal transduction cascade involved in several processes, including neurodevelopment. The lipid phosphatase DAF-18/PTEN inhibits the PI3K signaling ...