Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles a re still poorly understood. Particularly incipient is our knowledge ...

Perturbed neuronal proteostasis is a salient feature shared by both aging and protein misfolding disorders. The proteostasis network controls the health of the proteome by integrating pathways involved in protein synthesis, ...

The endoplasmic reticulum is one of the most studied and fascinating organelles. It is found in all eukaryotic cells and performs a variety of functions. The organelle was designated by this name by Keith Porter in 1953 ...

The highly polarized morphology and complex geometry of neurons is determined to a great extent by the structural and functional organization of the secretory pathway. It is intuitive to propose that the spatial arrangement ...

The cerebral dopamine neurotrophic factor (CDNF) is a peptide of 187 amino acids located in the endoplasmic reticulum of numerous cell types and evolutionarily conserved. CDNF exerts a protective effect on neurons in ...

Melanins are dark, insoluble pigments that are resistant to concentrated acids and bleaching by oxidising agents. Phytomelanin (or phytomelan) is present in the seed coat of some Asparagales and in the fruits of some ...