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Surgical treatment of pancreatic endocrine tumors in multiple endocrine neoplasia type 1
(Faculdade de Medicina / USP, 2012)
Surgical approaches to pancreatic endocrine tumors associated with multiple endocrine neoplasia type 1 may differ greatly from those applied to sporadic pancreatic endocrine tumors. Presurgical diagnosis of multiple endocrine ...
Pituitary tumors in patients with MEN1 syndrome
(Faculdade de Medicina / USP, 2012)
We briefly review the characteristics of pituitary tumors associated with multiple endocrine neoplasia type 1. Multiple endocrine neoplasia type 1 is an autosomal-dominant disorder most commonly characterized by tumors of ...
Tumor-associated macrophages induce endocrine therapy resistance in ER+ breast cancer cells
(MDPI AG, 2019-02)
Antiestrogenic adjuvant treatments are first-line therapies in patients with breast cancer positive for estrogen receptor (ER+). Improvement of their treatment strategies is needed because most patients eventually acquire ...
A simple method to assess estrogen receptor gene (ESR1) amplification in paired biopsies from primary tumor and recurrence in breast cancer patients receiving endocrine therapy
(2020)
Globally, Breast Cancer (BC) is the leading cause of cancer death among women. About 75% of patients are diagnosed with hormone-dependent tumors and are set to receive Endocrine Therapy (ET) targeting the estrogen receptor. ...
Metabolic adaptations in an endocrine-related breast cancer mouse model unveil potential markers of tumor response to hormonal therapy
(Frontiers Media, 2022-03)
Breast cancer (BC) is the most common type of cancer in women and, in most cases, it is hormone-dependent (HD), thus relying on ovarian hormone activation of intracellular receptors to stimulate tumor growth. Endocrine ...
Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression
(Impact Journals, 2015-06-08)
Improved efficacy of neoadjuvant endocrine-targeting therapies in luminal breast carcinomas could be achieved with optimal use of pathway targeting agents. In a mouse model of ductal breast carcinoma we identify a tumor ...
Managing common endocrine disorders amid COVID-19 pandemic
Background and aims: The novel coronavirus disease (COVID-19) pandemic and the resulting nationwide
lockdowns have posed a major challenge to the management of pre-existing and newly diagnosed
endocrine disorders. Herein, ...