Buscar
Mostrando ítems 1-10 de 46
The Cholinergic Lateral Line Efferent Synapse: Structural, Functional and Molecular Similarities With Those of the Cochlea
(Frontiers Media, 2021-10)
Vertebrate hair cell (HC) systems are innervated by efferent fibers that modulate their response to external stimuli. In mammals, the best studied efferent-HC synapse, the cholinergic medial olivocochlear (MOC) efferent ...
Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses
(The Royal Society, 2013-06)
Spontaneous electrical activity generated by developing sensory cells and neurons is crucial for the maturation of neural circuits. The full maturation of mammalian auditory inner hair cells (IHCs) depends on patterns of ...
Unravelling the molecular players at the cholinergic efferent synapse of the zebrafish lateral line
(Society for Neuroscience, 2020-11)
The lateral line (LL) is a sensory system that allows fish and amphibians to detect water currents. LL responsiveness is modulated by efferent neurons which aid to distinguish between external and self-generated stimuli, ...
Cochlear hair cells: The sound-sensing machines
(Elsevier, 2015-08-31)
The sensory epithelium of the mammalian inner ear contains two types of mechanosensory cells:inner (IHC) and outer hair cells (OHC). They both transduce mechanical force generated by soundwaves into electrical signals. In ...
Functional postnatal maturation of the medial olivocochlear efferent-outer hair cell synapse
(Society for Neuroscience, 2020-06-17)
The organ of Corti, the auditory mammalian sensory epithelium, contains two types of mechanotransducer cells, inner and outer hair cells (IHCs and OHCs, respectively). IHCs are involved in conveying acoustic stimuli to the ...
mGluR1 enhances efferent inhibition of inner hair cells in the developing rat cochlea
(Wiley Blackwell Publishing, Inc, 2017-06-01)
Key points: Spontaneous activity of the sensory inner hair cells shapes maturation of the developing ascending (afferent) auditory system before hearing begins. Just before the onset of hearing, descending (efferent) input ...
Short-term plasticity and modulation of synaptic transmission at mammalian inhibitory cholinergic olivocochlear synapses
(Frontiers, 2014-12-02)
The organ of Corti, the mammalian sensory epithelium of the inner ear, has two types of mechanoreceptor cells, inner hair cells (IHCs) and outer hair cells (OHCs). In this sensory epithelium, vibrations produced by sound ...
GABA modulation of olivocochlear efferent neurotransmission
(SAGE Publications, 2021)
During development, inner hair cells (IHCs) in the mammalian cochlea are unresponsive to acoustic stimuli but instead present intrinsic electrical activity, crucial for the normal development of the auditory pathway. During ...
SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells
(Academic Press Inc Elsevier Science, 2009-01)
Cochlear hair cells use SK2 currents to shape responses to cholinergic efferent feedback from the brain. Using SK2-/- mice, we demonstrate that, in addition to their previously defined role in modulating hair cell membrane ...
Developmental synaptic changes at the transient olivocochlear-inner hair cell synapse
(Society for Neuroscience, 2019-05-01)
In the mature mammalian cochlea, inner hair cells (IHCs) are mainly innervated by afferent fibers that convey sound information to the CNS. During postnatal development, however, medial olivocochlear (MOC) efferent fibers ...