Buscar
Mostrando ítems 1-10 de 993
Effect of pH and temperature on the immunogenicity of glycinin (Glycine max L)
(Kluwer Academic Publ, 1997-01-01)
Sensitive immunologic techniques for the detection of alterations that occur in protein antigens were used to evaluate the immunogenicity of soybean glycinin after isolation, heat denaturation and pH alteration. The objective ...
Immunogenicity in protein and peptide based-therapeutics: An overview
(Current Protein and Peptide Science, 2017-08)
Currently it is well known that all biological drugs, including those with a fully human structure, are capable of inducing a host immune response known as immunogenicity [1]. The presence of ADAs can condition the drug´s ...
Effect of pH and temperature on the immunogenicity of glycinin (Glycine max L)
(Kluwer Academic Publ, 1997-01-01)
Sensitive immunologic techniques for the detection of alterations that occur in protein antigens were used to evaluate the immunogenicity of soybean glycinin after isolation, heat denaturation and pH alteration. The objective ...
Effect of pH and temperature on the immunogenicity of glycinin (Glycine max L)
(Kluwer Academic Publ, 2014)
Immunomodulatory and immunogenic properties of mesenchymal stem cells derived from bovine fetal bone marrow and adipose tissue
(Elsevier B.V., 2019)
Little information is currently available on therapeutic features of bovine mesenchymal stem cells (MSCs), despite the development of large animal experimental models including cattle may open alternative strategies for ...
Effect of repetitiveness on the immunogenicity and antigenicity of Trypanosoma cruzi FRA protein
(Academic Press Inc Elsevier Science, 2011-03)
Repetitive proteins (RP) of Trypanosoma cruzi are highly present in the parasite and are strongly recognized by sera from Chagas' disease patients. Flagelar Repetitive Antigen (FRA), which is expressed in all steps of the ...
Immunogenicity to biological drugs in psoriasis and psoriatic arthritis
(Hospital Clinicas, Brasil, 2021)
Monoclonal antibodies or fusion proteins, defined as biological drugs, have modified the natural history of numerous immune-mediated disorders, allowing the development of therapies aimed at blocking the pathophysiological ...
Immunopeptidomic Data Integration to Artificial Neural Networks Enhances Protein-Drug Immunogenicity Prediction
(Frontiers Media S.A., 2020-06)
Recombinant DNA technology has, in the last decades, contributed to a vast expansion of the use of protein drugs as pharmaceutical agents. However, such biological drugs can lead to the formation of anti-drug antibodies ...
Foxp3 silencing with antisense oligonucleotide improves immunogenicity of an adjuvanted recombinant vaccine against sporothrix schenckii
(2021-04-01)
Background: In recent years, there has been great interest in developing molecular adjuvants based on antisense oligonucleotides (ASOs) targeting immunosuppressor pathways with inhibitory effects on regulatory T cells ...