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Tumour necrosis factor- released by testicular macrophages induces apoptosis of germ cells in autoimmune orchitis
(Oxford University Press, 2008-05)
BACKGROUND: Experimental autoimmune orchitis (EAO) is a model of chronic inflammation and infertility useful for studying testicular immune and germ cell (GC) interactions. In this model, EAO was induced in rats by ...
Death receptor and mitochondrial pathways are involved in germ cell apoptosis in an experimental model of autoimmune orchitis
(Oxford University Press, 2006-12)
Background: Studies on experimental autoimmune orchitis (EAO) have helped to elucidate immunological mechanisms involved in testicular damage. We previously demonstrated that EAO is characterized by lymphomononuclear cell ...
Functional and phenotypical characteristics of testicular macrophages in experimental autoimmune orchitis
(John Wiley & Sons Ltd, 2008-01-22)
Testicular inflammation with compromised fertility can occur despite the fact that the testis is considered an immunoprivileged organ. Testicular macrophages have been described as cells with an immunosuppressor profile, ...
Differential changes in CD4+ and CD8+ effector and regulatory T lymphocyte subsets in the testis of rats undergoing autoimmune orchitis
(Elsevier Ireland, 2009-07)
Experimental autoimmune orchitis (EAO) is a useful model to study chronic testicular inflammation and infertility. EAO is characterized by severe damage of seminiferous tubules with germ cells that undergo apoptosis and ...
Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis
(Elsevier Ireland, 2006-06)
Experimental autoimmune orchitis (EAO) is an organ-specific model of autoimmunity characterized by an interstitial lymphomononuclear cell infiltrate as well as sloughing and apoptosis of germ cells. EAO was induced in adult ...
Pathomechanisms of autoimmune based testicular inflammation
(Frontiers Media, 2020-09)
Infection and inflammation of the male reproductive tract are relevant causes of infertility. Inflammatory damage occurs in the special immunosuppressive microenvironment of the testis, a hallmark termed testicular immune ...
Experimental autoimmune orchitis as a model of immunological male infertility
(Springer Tokyo, 2012-12)
Clinically, 60-75% of male infertility cases are categorized as idiopathic spermatogenic disturbance. In previous studies of this condition, lymphocytic infiltration and immune deposits were present in several testis biopsy ...
Involvement of soluble Fas Ligand in germ cell apoptosis in testis of rats undergoing autoimmune orchitis
(Elsevier, 2012-11)
Experimental autoimmune orchitis (EAO) is a model of chronic inflammation and infertility useful for studying immune and germ cell (GC) interactions. EAO is characterized by severe damage of seminiferous tubules (STs) with ...
Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord
(Nature Publishing Group, 2020-01)
The aim of this work was to study effects of ketotifen fumarate (KF) on prevention of tissue damage in testes of rats with experimental autoimmune orchitis (EAO) and on the contralateral testis in a model of prolonged ...
Characterization of dendritic cells in testicular draining lymph nodes in a rat model of experimental autoimmune orchitis
(Wiley Blackwell Publishing, Inc, 2011-06)
The maturation state of dendritic cells (DC) is regarded as a control point for the induction of peripheral tolerance or autoimmunity. Experimental autoimmune orchitis (EAO) serves as a model to investigate inflammatory-based ...