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The "First Hit" Toward Alcohol Reinforcement: Role of Ethanol Metabolites
(Wiley-Blackwell, 2015)
This review analyzes literature that describes the behavioral effects of 2 metabolites of ethanol (EtOH):
acetaldehyde and salsolinol (a condensation product of acetaldehyde and dopamine) generated in the
brain. These ...
The Alcohol Deprivation Effect:Marked Inhibition by Anticatalase Gene Administration into the Ventral Tegmental Area in Rats
(2013)
Background: Animals that have chronically consumed alcohol and are subsequently deprived of it
markedly increase their intake above basal levels when access to alcohol is reinstated. Such an effect,
termed the alcohol ...
The role of acetaldehyde in ethanol reinforcement assessed by Pavlovian conditioning in newborn rats
(Springer, 2013-04)
Rationale: Animal studies indicate that central acetaldehyde, dependent on catalase metabolism of ethanol (EtOH), modulates ethanol reinforcement. Brain catalase activity and acetaldehyde (ACD) production are significantly ...
Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in ratsLa administración sistémica e intra-accumbens del agonista 5-HT1B CP94253 modula la auto-administración oral de etanol en ratas
(Universidad Nacional de Córdoba, 2022)
Beyond the "First Hit": Marked Inhibition by N-Acetyl Cysteine of Chronic Ethanol Intake But Not of Early Ethanol Intake. Parallel Effects on Ethanol-Induced Saccharin Motivation
(Wiley-Blackwell, 2016)
Background: A number of studies have shown that acetaldehyde synthesized in the brain is necessary to induce ethanol (EtOH) reinforcement in naive animals (acquisition phase). However, after chronic intake is achieved ...
Commonality of Ethanol and Nicotine Reinforcement and Relapse inWistar-Derived UChB Rats: Inhibition by N-Acetylcysteine
(2018)
Background: Life expectancy is greatly reduced in individuals presenting alcohol use disorders and chronic smoking. Literature studies suggest that common mechanisms may apply to the chronic use and relapse of both alcohol ...
Modulation of ethanol-metabolizing enzymes by developmental lead exposure: Effects in voluntary ethanol consumption
(Frontiers Media S.A., 2017-05-23)
This review article provides evidence of the impact of the environmental contaminant lead (Pb) on the pattern of the motivational effects of ethanol (EtOH). To find a mechanism that explains this interaction, the focus of ...
Effect of a positive reinforcing stimulus on fear memory reconsolidation in ethanol withdrawn rats: Influence of D-cycloserine
(Elsevier Science, 2016-12)
The pharmacological blockade of memory reconsolidation has been suggested as a potential treatment to the attenuation of maladaptive memories associated to psychiatric disorders and drug addiction. To interfere with the ...
Ethanol-Related Learning in Rat Neonates Impact upon Apneic Episodes and Promote Seeking Behavior of Stimuli that Signaled the State of Intoxication
(Dougmar Publishing Group, 2019)
In rats, high ethanol doses during early postnatal life exert deleterious effects upon brain development that impact on social and cognitive abilities. This stage in development partially overlaps with the 3rd human ...