The role of cytokines in modulating the formation of new tumors is mediated by their ability to regulate antigen-specific anti-tumor responses and by the activation of non-specific mechanisms, including those involved in ...

Cytotoxic drugs remain the first-line option for cancer therapy but the development of drug-resistance by tumor cells represents a primary obstacle for successful chemotherapy. Autophagy is a physiological mechanism of ...

Galectins are glycan‐binding proteins implicated in several biological activities such as intracellular signaling, cell‐cell communication, cellular proliferation and survival. These endogenous lectins have emerged as key ...

Despite the existence of tumor-specific immune cells, most tumors have devised strategies to avoid immune attack. We demonstrate here that galectin-1 (Gal-1), a negative regulator of T cell activation and survival, plays ...

Despite major advances in the understanding of tumor rejection mechanisms, the successful translation of basic and preclinical information into an effective tumor immunotherapy in the clinic has continued to falter. It has ...

Tumors may usurp certain mediators and signaling pathways used by normal cells to evade or shift immune responses (1). Unlocking these mechanisms may help the implementation of novel therapeutic approaches in cancer patients. ...