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The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer
(2017)
Gallbladder cancer (GBC) is a highly fatal disease with poor prognosis and few therapeutic alternatives. Molecular profiling has revealed that the deregulation in the ERK/MAPK signaling pathway plays a crucial role in many ...
Prolactin gene expression in the pituitary of rats subjected to vaginocervical stimulation requires Erk-1/2 signaling
(Institute animal reproduction food research, 2017)
Vaginocervical stimulation (VCS) induces twice-daily prolactin (PRL) surges resulting in pseudopregnancy in the rat. Furthermore, activation of the extracellular signal-regulated kinase-1/2 (Erk-1/2) is involved in the ...
Role of the ERK1/2 signaling pathway in the replication of junín and tacaribe viruses
(MDPI, 2018-04)
We have previously shown that the infection of cell cultures with the arenaviruses Junín (JUNV), Tacaribe (TCRV), and Pichindé promotes the phosphorylation of mitogen-activated protein kinases (MAPKs) extracellular ...
ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
(Frontiers Media S.A., 2018-10)
Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we ...
Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding
(American Chemical Society, 2016-03)
The mitogen-activated protein kinase ERK2 is able to elicit a wide range of context-specific responses to distinct stimuli, but the mechanisms underlying this versatility remain in question. Some cellular functions of ERK2 ...
Calcium, iron and neuronal function
(2007)
Calcium and iron play dual roles in neuronal function: they are both essential but when present in excess they cause neuronal damage and may even induce neuronal death. Calcium signals are required for synaptic plasticity, ...
Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
(Sociedad de Biología de Chile, 2006)
Regulation of p21Waf1 expression and TNF alpha(biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: Involvement of JNK and ERK pathways
(Elsevier B.V., 2007-11-30)
Oxidative modifications of proteins are fundamental biochemical events that regulate cellular signaling, protein expression, and function. the redox status is balanced by reductants in which GSH plays a major role. This ...
T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells
(Society of Biology of Chile, 2002)
Serum levels of T-kininogen increase dramatically as rats approach the end of their lifespan. Stable expression of the protein in Balb/c 3T3 fibroblasts leads to a dramatic inhibition of cell proliferation, as well as ...
Angiotensin II Signaling in Human Preadipose Cells: Participation of ERK1,2-Dependent Modulation of Akt
(2013-10)
The renin-angiotensin system expressed in adipose tissue has been implicated in the modulation of adipocyte formation,
glucose metabolism, triglyceride accumulation, lipolysis, and the onset of the adverse metabolic ...