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ErbB-2 nuclear function in breast cancer growth, metastasis and resistance to therapy
(BioScientifica, 2016-10)
Approximately 15-20% of breast cancers (BC) show either membrane overexpression of ErbB-2 (MErbB-2), a member of the ErbBs family of receptor tyrosine kinases, or ERBB2 gene amplification. Until the development of ...
Nuclear ErbB-2: A Novel Therapeutic Target in ErbB-2-Positive Breast Cancer?
(Springer, 2019-01)
Membrane overexpression of ErbB-2 (MErbB-2), a member of the ErbB family of receptor tyrosine kinases, occurs in 15– 20% of breast cancers (BC) and constitutes a therapeutic target in this BC subtype (ErbB-2-positive). ...
Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance
(Nature Publishing Group, 2015-06)
Membrane overexpression of ErbB-2/HER2 receptor tyrosine kinase (membrane ErbB-2 (MErbB-2)) has a critical role in breast cancer (BC). We and others have also shown the role of nuclear ErbB-2 (NErbB-2) in BC, whose presence ...
Progesterone Receptor Induces ErbB-2 Nuclear Translocation To Promote Breast Cancer Growth via a Novel Transcriptional Effect: ErbB-2 Function as a Coactivator of Stat3
(American Society For Microbiology, 2010-12)
Progesterone receptor (PR) and ErbB-2 bidirectional cross talk participates in breast cancer development. Here, we identified a new mechanism of the PR and ErbB-2 interaction involving the PR induction of ErbB-2 nuclear ...
Efectos nucleares del receptor Tirosina Quinasa ErbB-2 en cáncer de mama
(Ediciones Médicas del Sur, 2017-08)
Aproximadamente 15-20% de los cánceres de mama (CM) presentan sobre- expresiónen la membrana citoplasmáticade ErbB-2 (MErbB-2), un miembro de la familia ErbBs de receptores con actividad de tirosina quinasa, o bien presentan ...
Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis
(Nature Publishing Group, 2015)
Membrane overexpression of the receptor tyrosine kinase ErbB-2 (MErbB-2) accounts for a clinically aggressive breast cancer (BC) subtype (ErbB-2-positive) with increased incidence of metastases. We and others demonstrated ...
Progestin drives breast cancer growth by inducing p21CIP1 expression through the assembly of a transcriptional complex among Stat3, progesterone receptor and ErbB-2
(Elsevier, 2013-06-30)
Cell cycle regulator p21CIP1 has controversial biological effects in breast cancer since in spite of its role as cell cycle inhibitor and promoter of cellular senescence, it also induces cell proliferation and chemoteraphy ...
Cooverexpression Of Erbb1 And Erbb4 Receptors Predicts Poor Clinical Outcome In Pn+ Oral Squamous Cell Carcinoma With Extranodal Spread
(Springer Science and Business Media Netherlands, 2014)
The molecular basis of progesterone receptor action in breast carcinogenesis
(De Gruyter, 2012-04)
Progesterone plays an essential role in the regulation of cell proliferation and differentiation in the mammary gland. In addition, experimental and clinical evidence points to a critical role of progesterone and the ...
Interacciones entre factores de crecimiento (GFs) y el receptor de progesterona (PR) en cáncer de mama.Growth factors (GFs) and progesterone receptor (PR) crosstalks in breast cancerInterações entre fatores de crescimento (GFs) e o receptor de progesterona (PR) em câncer de mama
(Federación Bioquímica de la Provincia Buenos Aires, 2011-12)
En trabajos previos hemos demostramos la existencia de interacciones bi-direccionales entre las vías de los progestá- genos y de la heregulina (HRG) en cáncer mamario. Encontramos que los progestágenos regulan la actividad ...