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Identification of epsilon PKC Targets During Cardiac Ischemic Injury
(JAPANESE CIRCULATION SOCKYOTO, 2012)
Background: Epsilon-protein kinase C (epsilon PKC) protects the heart from ischemic injury. However, the mechanism(s) of epsilon PKC cardioprotection is still unclear. Identification of the epsilon PKC targets may aid in ...
The role of PKA and PKC epsilon pathways in prostaglandin E(2)-mediated hypernociception
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Background and purpose: Protein kinase (PK) A and the epsilon isoform of PKC (PKC epsilon) are involved in the development of hypernociception (increased sensitivity to noxious or innocuous stimuli) in several animal models ...
Ischaemic preconditioning improves proteasomal activity and increases the degradation of delta PKC during reperfusion
(OXFORD UNIV PRESS, 2010)
The response of the myocardium to an ischaemic insult is regulated by two highly homologous protein kinase C (PKC) isozymes, delta and epsilon PKC. Here, we determined the spatial and temporal relationships between these ...
The peripheral pro-nociceptive state induced by repetitive inflammatory stimuli involves continuous activation of protein kinase A and protein kinase C epsilon and its Na(v)1.8 sodium channel functional regulation in the primary sensory neuron
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
In the present study, the participation of the Na(v)1.8 sodium channel was investigated in the development of the peripheral pro-nociceptive state induced by daily intraplantar injections of PGE(2) in rats and its regulation ...
Acute and persistent nociceptive paw sensitisation in mice: The involvement of distinct signalling pathways
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Aims: Many fundamental pharmacological studies in pain and inflammation have been performed on rats. However, the pharmacological findings were generally not extended to other species in order to increase their predictive ...
Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway
(Elsevier Science, 2017-04)
PKCε, an oncogenic member of the PKC family, is aberrantly overexpressed in epithelial cancers. To date, little is known about functional interactions of PKCε with other genetic alterations, as well as the effectors ...