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The interplay between long noncoding rnas and proteins of the epigenetic machinery in ovarian cancer
(2020-09-01)
Comprehensive large-scale sequencing and bioinformatics analyses have uncovered a myriad of cancer-associated long noncoding RNAs (lncRNAs). Aberrant expression of lncRNAs is associated with epigenetic reprogramming during ...
Epigenetics of brain aging
(Universidad Continental, 2018-01-01)
The complexity of human aging and longevity results from a combination of genetic, epigenetic, and environmental factors. Epigenetic mechanisms, including DNA methylation, chromatin structure, and RNA interference, regulate ...
Epigenetic pathways regulating bone homeostasis:Potential targeting for intervention of skeletal disorders
(Current Medicine Group LLC 1, 2014)
Epigenetic regulation utilizes different mechanisms to convey heritable traits to progeny cells that are independent of DNA sequence, including DNA silencing, posttranslational modifications of histone proteins, and the ...
Epigenetic alterations related to early-life stressful events
(Cambridge University Press, 2012)
Objective Early stress events severely impact brain and behaviour. From a neurobiological point of view early stress influences neuroanatomical structures and is associated with a dysregulation of the hypothalamic-pituit ...
Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix
(2012)
Cervical cancer (CC) is one of the most malignant tumors and the second or third most common type of cancer in women worldwide. The association between human papillomavirus (HPV) and CC is widely known and accepted (99.7% ...
The Burden of Genetic and Epigenetic Traits in Prematurity
(2018-04-01)
Despite decades of investigations and accumulated scientific knowledge, preterm birth (PTB) remains a significant burden worldwide. Several mechanisms have been proposed to explain this condition, and a number of risk ...
Epigenetic Changes and Chromatin Reorganization in Brain Function: Lessons from Fear Memory Ensemble and Alzheimer’s Disease
(MDPI, 2022-10)
Healthy brain functioning in mammals requires a continuous fine-tuning of gene expression. Accumulating evidence over the last three decades demonstrates that epigenetic mechanisms and dynamic changes in chromatin organization ...