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Expression of the epidermal stem cell marker p63/CK5 in cutaneous papillomas and cutaneous squamous cell carcinomas of dogs
(Elsevier, 2021-03)
Cutaneous papillomas (CPs) and cutaneous squamous cell carcinomas (CSCCs) are usual epidermal tumours in dogs. CPs and CSCCs probably arise from the neoplastic transformation of the keratinocytes within the stem cell ...
Aberrant expression of E-cadherin/β-catenin during epidermal tumourigenesis in dogs
(Elsevier, 2020-04)
Clinically relevant epidermal tumours in dogs include cutaneous papillomas (CPs) and cutaneous squamous cell carcinomas (CSCCs). The development of CPs and CSCCs involves dysregulation in expression of E-cadherin/β-catenin; ...
Expression of the hippo signalling pathway effector YAP during canine epidermal tumourigenesis
(Elsevier, 2020-06)
Cutaneous papilloma (CP) and cutaneous squamous cell carcinoma (CSCC) are frequent epidermal tumours in dogs. In this regard, the study of the deregulated activity of signalling molecules during the epidermal tumourigenesis ...
Matrix metalloproteinases, TIMPs and growth factors regulating ameloblastoma behaviour
(WILEY-BLACKWELL, 2010)
Aims: Ameloblastoma is an odontogenic neoplasm with local invasiveness and recurrence. We have previously suggested that growth factors and matrix metalloproteinases (MMPs) influence ameloblastoma invasiveness(1). The aim ...
Tissue-resident memory CD8(+) T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells
(Facultad de Medicina y Ciencia, 2019)
Tissue-resident memory CD8(+) T (Trm) cells mediate potent local innate and adaptive immune responses and play a central role against solid tumors. However, whether Trm cells cross-talk with dendritic cells (DCs) to support ...
Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas
(Elsevier, 2020-01)
The molecular mechanisms contributing to the development of cutaneous papillomas (CPs) and cutaneous squamous cell carcinomas (CSCCs) are still poorly understood, limiting the ability to identify molecular suitable targets ...
Prognostic Factors in Canine Mammary Carcinomas and HER2 Expression Relationship
(Universidade Federal do Rio Grande do Sul, 2017)
Absence of transforming growth factor-beta type II receptor is associated with poorer prognosis in HER2-negative breast tumours
(Oxford University Press, 2010-04-01)
Background: The clinical relevance of transforming growth factor-beta (TGF-beta)-signalling pathway in breast carcinomas (BCs) remained elusive. This study aimed to evaluate the prognostic value of TGF-beta and transforming ...
Absence of transforming growth factor-beta type II receptor is associated with poorer prognosis in HER2-negative breast tumours
(Oxford University Press, 2010-04-01)
Background: The clinical relevance of transforming growth factor-beta (TGF-beta)-signalling pathway in breast carcinomas (BCs) remained elusive. This study aimed to evaluate the prognostic value of TGF-beta and transforming ...