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ProtMiscuity: a database of promiscuous proteins
(Oxford University Press, 2019-01)
Promiscuous behaviour in proteins and enzymes remains a challenging feature to understand the structure-function relationship. Here we present ProtMiscuity, a manually curated online database of proteins showing catalytic ...
The promiscuous phosphomonoestearase activity of Archaeoglobus fulgidus CopA, a thermophilic Cu+ transport ATPase
(Elsevier Science, 2016-07-14)
Membrane transport P-type ATPases display two characteristic enzymatic activities: a principal ATPase activity provides the driving force for ion transport across biological membranes, whereas a promiscuous secondary ...
Emergence of pyridoxal phosphorylation through a promiscuous ancestor during the evolution of hydroxymethyl pyrimidine kinases
(Elsevier, 2014)
In the family of ATP-dependent vitamin kinases, several bifunctional enzymes that phosphorylate
hydroxymethyl pyrimidine (HMP) and pyridoxal (PL) have been described besides enzymes specific
towards HMP. To determine how ...
Allosteric control of substrate specificity of the Escherichia coli ADP-glucose pyrophosphorylase
(Frontiers Research Foundation, 2017-06)
The substrate specificity of enzymes is crucial to control the fate of metabolites to different pathways. However, there is growing evidence that many enzymes can catalyze alternative reactions. This promiscuous behavior ...
Allosteric Control of Substrate Specificity of the Escherichia coli ADP-Glucose Pyrophosphorylase
(Frontiers Research Foundation, 2017-06)
The substrate specificity of enzymes is crucial to control the fate of metabolites to different pathways. However, there is growing evidence that many enzymes can catalyze alternative reactions. This promiscuous behavior ...
The Ancestral Activation Promiscuity of ADP-glucose Pyrophosphorylase from Photosynthetic Organisms
(Biomed Central, 2013-02)
ADP-glucose pyrophosphorylase (ADP-Glc PPase) catalyzes the first committed step in the synthesis of glycogen in bacteria and starch in algae and plants. In oxygenic photosynthetic organisms, ADP-Glc PPase is mainly activated ...
Promiscuous subunit interactions: A possible mechanism for the regulation of protein kinase CK2
(1998)
Protein kinase CK2 is a ubiquitous eukaryotic ser/thr protein kinase. The active holoenzyme is a heterotetrameric protein corn posed of catalytic (α and α') and regulatory (β) subunits that phosphorylates many different ...
Hyperstability and substrate promiscuity in laboratory resurrections of precambrian β-lactamases
(American Chemical Society, 2013-02)
We report a sequence reconstruction analysis targeting several Precambrian nodes in the evolution of class-A β-lactamases and the preparation and experimental characterization of their encoded proteins. Despite extensive ...