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Competing endogenous RNA networks in the epithelial to mesenchymal transition in diffuse-type of gastric cancer
(MDPI, 2020)
The diffuse-type of gastric cancer is associated with epithelial to mesenchymal transition. Loss of E-cadherin expression is the hallmark of this process and is largely due to the upregulation of the transcription factors ...
Is the Epithelial-to-Mesenchymal Transition Clinically Relevant for the Cancer Patient?
(Bentham Science Publishers, 2011-04)
Abstract: Epithelial-to-mesenchymal transition (EMT) is a transdifferentiation process by which a fully differentiated epithelial cell acquires mesenchymal traits, and therefore, mesenchymal abilities such as motility and ...
TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines
(Wiley, 2019)
Transient Receptor Potential Melastatin 4 (TRPM4) is a Ca2+‐activated and voltage‐
dependent monovalent cation channel, which depolarizes the plasma cell membrane,
thereby modulating Ca2+ influx across Ca2+‐permeable ...
SPARC induces E-cadherin repression and enhances cell migration through integrin v beta 3 and the transcription factor ZEB1 in prostate cancer cells
(MDPI, 2022)
Secreted protein acidic and rich in cysteine (SPARC), or osteonectin, is a matricellular protein that modulates interactions between cells and their microenvironment. SPARC is expressed during extracellular matrix remodeling ...
The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines
(2019)
One of the factors promoting tumoral progress is the abnormal activation of the epithelial-mesenchymal transition (EMT) program which has been associated with chemoresistance in tumoral cells. The transcription factor zinc ...
ETV5 transcription factor is upregulated in ovarian cancer and contributes to ovarian tumor progression and dissemination
(Wiley, 2011-08)
Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators ...
PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells
(eLife Sciences Publications Ltd, 2016-06)
Mutations in PROP1 are the most common cause of hypopituitarism in humans; therefore, unraveling its mechanism of action is highly relevant from a therapeutic perspective. Our current understanding of the role of PROP1 in ...
Secreted protein acidic and rich in cysteine (SPARC) induces epithelial-mesenchymal transition, enhancing migration and invasion, and is associated with high Gleason score in prostate cancer
(2019)
Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein highly expressed in bone tissue that acts as a chemoattractant factor promoting the arrival of prostate cancer (PCa) cells to the bone marrow. ...
The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines
(NLM (Medline), 2019)
One of the factors promoting tumoral progress is the abnormal activation of the epithelial-mesenchymal transition (EMT) program which has been associated with chemoresistance in tumoral cells. The transcription factor zinc ...
Gamma secretase inhibitor impairs epithelial-to-mesenchymal transition induced by TGF-β in ovarian tumor cell lines
(Elsevier Ireland, 2017-01)
Ovarian cancer is characterized by being highly metastatic, a feature that represents the main cause of failure of the treatment. This study investigated the effects of γ-secretase inhibition on the TGF-β-induced ...