Buscar
Mostrando ítems 1-10 de 14
Multicomponent synthesis of antibacterial dihydropyridin and dihydropyran embelin derivative
(American Chemical Society, 2013-07)
A series of dihydropyran and dihydropyridin embelin derivatives were synthesized through a novel and straightforward, one pot protocol based on a three component reaction with embelin, aldehydes and cyclic enaminones as ...
Development and validation of a mechanistic model for the release of embelin from a polycaprolactone matrix
(Elsevier, 2020-11)
Embelin is a natural agent with antimicrobial, antifungal and analgesic activities. This work presents a mechanistic model for the release of embelin from a polycaprolactone matrix. Based on the results of embelin release ...
Multilayered electrospun nanofibrous scaffolds for tailored controlled release of embelin
(Taylor & Francis, 2018-01)
Polymeric electrospun meshes are highly attractive as versatile platforms for numerous biomedical applications, tissue engineering, biosensors, and controlled release of bioactive agents. Herein, we describe the preparation ...
Bioactive alkyl phenols and embelin from Oxalis erythrorhiza
(Elsevier Ireland Ltd, 2007)
Domino Synthesis of Embelin Derivatives with Antibacterial Activity
(American Chemical Society, 2016-02)
A series of dihydropyran embelin derivatives was synthesized through a direct and highly efficient approach based on a domino Knoevenagel intramolecular hetero-Diels–Alder reaction from natural embelin (1), using unsaturated ...
Dispersion and release of embelin from electrospun biodegradable, polymeric, membranes
(Nature Publishing Group, 2012-05-16)
In this work, microfiber meshes containing embelin, a poorly water-soluble bioactive agent, were prepared by solubilizing embelin in a biodegradable and biocompatible polymer matrix of poly(ε-caprolactone) (PCL). Plain or ...
Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone
Background: Quinones are reactive to proteins containing cysteine residues and the main protease
in Covid-19 contains an active site that includes Cys145. Embelin, a quinone natural product, is
known to have antiviral ...
Microwave-Assisted Organocatalytic Intramolecular Knoevenagel/Hetero Diels–Alder Reaction with O -(Arylpropynyloxy)-Salicylaldehydes: Synthesis of Polycyclic Embelin Derivatives
(American Chemical Society, 2016-10)
highly efficient and regioselective approach to new polycyclic embelin derivatives through a domino Knoevenagel condensation/intramolecular hetero Diels−Alder reaction using O-(arylpropynyloxy)-salicylaldehydes in the ...
Dispersion and release of embelin from electrospun, biodegradable, polymeric membranes
(Nature Publishing GroupNew YorkEUA, 2012)
Efficient multicomponent synthesis of diverse antibacterial embelin-privileged structure conjugates
(Molecular Diversity Preservation International, 2020-07)
A library of embelin derivatives has been synthesized through a multicomponent reaction from embelin (1), aldehydes and privileged structures such as 4-hydroxycoumarin, 4-hydroxy-2H-pyran-2-one and 2-naphthol, in the ...