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Intradermal DNA electroporation induces survivin-specific CTLs, suppresses angiogenesis and confers protection against mouse melanoma
(2010)
Survivin is an intracellular tumor-associated antigen that is broadly expressed in a large variety of tumors and also in tumor associated endothelial cells but mostly absent in differentiated tissues. Naked DNA vaccines ...
Towards an optimal dose-response relationship in gene electrotransfer protocols
(Pergamon-Elsevier Science Ltd, 2019-10-01)
In search of an optimal gene electrotransfer (GET) protocol, an electroporation-based (EP) tumor treatment with great potential as a non-viral gene-delivery system, the concept of the dose-response relationship is introduced. ...
The role of pH fronts in tissue electroporation based treatments
(Public Library Science, 2013-11)
Treatments based on electroporation (EP) induce the formation of pores in cell membranes due to the application of pulsed electric fields. We present experimental evidence of the existence of pH fronts emerging from both ...
Electroporation optimizes the uptake of boron-10 by tumor for boron neutron capture therapy (BNCT) mediated by GB-10: a boron biodistribution study in the hamster cheek pouch oral cancer model
(Springer, 2019-05)
Boron neutron capture therapy (BNCT) is a promising cancer binary therapy modality that utilizes the nuclear capture reaction of thermal neutrons by boron-10 resulting in a localized release of high- and low-linear energy ...
Electrochemotherapy associated with calcium electroporation in metastatic feline cutaneous malignant melanoma
(2019-01-01)
Background: Calcium electroporation (CaEP) is a novel therapeutic treatment that has been studied for cancer due to its selective killing cancer cells by necrosis and danger signals. Besides that, electrochemotherapy (ECT) ...
The Role of Additional Pulses in Electropermeabilization Protocols
(Public Library of Science, 2014-12)
Electropermeabilization (EP) based protocols such as those applied in medicine, food processing or environmental management, are well established and widely used. The applied voltage, as well as tissue electric conductivity, ...
Electrochemotherapy Associated with Calcium Electroporation in Metastatic Feline Cutaneous Malignant Melanoma
(Universidade Federal do Rio Grande do Sul, 2019)
Intradermal DNA electroporation induces survivin-speciWc CTLs, suppresses angiogenesis and confers protection against mouse melanoma
(Springer-Verlag, 2010)
Survivin is an intracellular tumor-associated
antigen that is broadly expressed in a large variety of
tumors and also in tumor associated endothelial cells but
mostly absent in diVerentiated tissues. Naked DNA ...
Effects of pulse addition in electropermeabilization: Theoretical insights on the electric conductivity
(Springer, 2016-11)
The electrochemical treatment (ECT) of solid tumors is an electropermeabilization technique firmly established and widely used. In ECT protocols, pulse intensity as well as tissue electric conductivity are of utmost ...
Estudo comparativo de protocolos de imunização gênica: eletroporação aumenta consistentemente a resposta imune humoral
(Universidade Federal de São Paulo (UNIFESP), 2008-03-26)
Gene immunization may bypass some difficulties found with protein immunogen, such as the obtainment of purified antigen and the immune response reactivity to its native conformation. Thus, antigen encoding DNA inserted ...