Buscar
Mostrando ítems 1-10 de 241
Seedling signalling: Ubiquitin ligases acting in tandem
(Macmillan, 2016-02)
Buried seedlings must grow both strongly, to push through soil to the surface, and fast, to reach the light as quickly as possible. A recent study finds that a pair of sequentially acting E3 ubiquitin ligases balances these ...
Characterization of the Arabidopsis thaliana E3 Ubiquitin-Ligase AtSINAL7 and identification of the Ubiquitination sites
(Public Library Science, 2013-08)
Protein ubiquitination leading to degradation by the proteasome is an important mechanism in regulating key cellular functions. Protein ubiquitination is carried out by a three step process involving ubiquitin (Ub) activation ...
Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase
(Cell Press, 2013-03)
F-box proteins and DCAF proteins are the substrate binding subunits of the Skp1-Cul1-F-box protein (SCF) and Cul4-RING protein ligase (CRL4) ubiquitin ligase complexes, respectively. Using affinity purification and mass ...
High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy
(Nature, 2014-05)
Inhibition of distinct ubiquitin E3 ligases might represent a powerful therapeutic tool. ITCH is a HECT domain-containing E3 ligase that promotes the ubiquitylation and degradation of several proteins, including p73, p63, ...
How Many Faces Does the Plant U-Box E3 Ligase Have?
(MDPI, 2022)
The E3 ubiquitin-ligase SEVEN IN ABSENTIA like 7 mono-ubiquitinates glyceraldehyde-3-phosphate dehydrogenase 1 isoform in vitro and is required for its nuclear localization in Arabidopsis thaliana
(Pergamon-Elsevier Science Ltd, 2016-01)
The E3 ubiquitin-protein ligases are associated to various processes such as cell cycle control and diverse developmental pathways. Arabidopsis thaliana SEVEN IN ABSENTIA like 7, which has ubiquitin ligase activity, is ...
LEUCINE ATTENUATES SKELETAL MUSCLE WASTING VIA INHIBITION OF UBIQUITIN LIGASES
(JOHN WILEY & SONS INC, 2010)
The aim of this study was to assess the effect of leucine supplementation on elements of the ubiquitin proteasome system (UPS) in rat skeletal muscle during immobilization. This effect was evaluated by submitting the animals ...
Model of the Ankyrin and SOCS Box Protein, ASB9, E3 Ligase Reveals a Mechanism for Dynamic Ubiquitin Transfer
(2016)
Cullin-RING E3 ligases (CRLs) are elongated and bowed protein complexes that transfer ubiquitin over 60 angstrom to proteins targeted for proteasome degradation. One such CRL contains the ankyrin repeat and SOCS box protein ...