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Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release
(National Academy of Sciences, 2020-02)
Synaptotagmin 1 (Syt1) synchronizes neurotransmitter release to action potentials (APs) acting as the fast Ca2+ release sensor and as the inhibitor (clamp) of spontaneous and delayed asynchronous release. While the Syt1 ...
Evaluación de la participación de sinaptotagmina-i y la dinámica de distribución de Ca2+ en la hipofunción glandular en pacientes con Síndrome de Sjögren
(Universidad de Chile, 2016)
El Síndrome de Sjögren (SS) es una enfermedad autoinmune sistémica, que afecta
a las glándulas exocrinas, principalmente a las glándulas salivales y lagrimales, generando
en los pacientes síntomas de sequedad bucal y ...
ER–plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis
(Nature Publishing Group, 2017-07)
The double‐membrane‐bound autophagosome is formed by the closure of a structure called the phagophore, origin of which is still unclear. The endoplasmic reticulum (ER) is clearly implicated in autophagosome biogenesis due ...
Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren's syndrome patients
(Facultad de Odontología, 2019)
Sjogren's syndrome (SS) is an autoimmune exocrinopathy associated with severe secretory alterations by disruption of the glandular architecture integrity, which is fundamental for a correct function and localization of the ...
Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren's syndrome patients
(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2019)
Sjogren's syndrome (SS) is an autoimmune exocrinopathy associated with severe secretory alterations by disruption of the glandular architecture integrity, which is fundamental for a correct function and localization of the ...
Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjögren's syndrome patients
(2019-02)
Sjögren's syndrome (SS) is an autoimmune exocrinopathy associated with severe secretory alterations by disruption of the glandular architecture integrity, which is fundamental for a correct function and localization of the ...
Rearrangements under confinement lead to increased binding energy of Synaptotagmin-1 with anionic membranes in Mg2+ and Ca2+
(Elsevier Science, 2018-04)
Synaptotagmin-1 (Syt1) is the primary calcium sensor (Ca2+ ) that mediates neurotransmitter release at the synapse. The tandem C2 domains (C2A and C2B) of Syt1 exhibit functionally critical, Ca2+ -dependent interactions ...
Modulation of microglia and presynaptic protein expression after mesenchymal stem cells treatment in a rat model of Alzheimer's disease
(Elsevier, 2019-09)
Objectives: Sporadic Alzheimer´s disease (sAD) is the most prevalent neurodegenerative pathology with no effective therapy until date. This disease prompts hippocampal degeneration, which in turn affects multiple cognitive ...
THU0053 Three Dimensional HSG Cells Culture as A Model to Study the Exocitic Process in Salivary Glands of SjÖGren's Syndrome Patients
(CIENCIAS, 2014)
Background Labial salivary glands (LSG) from Sjögren's syndrome (SS) patients show impaired cell-polarity, alterations of SNARE proteins localization and presence of salivary mucins in the extracellular matrix. Exocytosis ...
Cryptic SYT/SXX1 fusion gene in high-grade biphasic synovial sarcoma with unique complex rearrangement and extensive BCL2 overexpression
(ELSEVIER SCIENCE INC, 2010)
Synovial sarcomas are high-grade malignant mesenchymal tumors that account for 10% of all soft-tissue sarcomas. Almost 95% of these tumors are characterized by a nonrandom chromosomal abnormality, t(X;18)(p11.2;q11.2), ...