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DNA repair genes in astrocytoma tumorigenesis, progression and therapy resistance
(2020-01-01)
Glioblastoma (GBM) is the most common and malignant type of primary brain tumor, showing rapid development and resistance to therapies. On average, patients survive 14.6 months after diagnosis and less than 5% survive five ...
Eficacia de la terapia dual para erradicación de H. pylori en una población colombiana
(Universidad Nacional de ColombiaBogotá - Medicina - Especialidad en Medicina InternaBogotá, 2021-01-25)
Introducción: Helicobacter pylori (H. pylori) afecta al 50% de la humanidad. Los tratamientos usuales han disminuido su eficacia por aumento de resistencia a los antibióticos excepto amoxicilina, tetraciclina, furazolidona ...
Gene transfer to primary corneal epithelial cells with an integrating lentiviral vector
(Conselho Brasileiro de Oftalmologia, 2010-10-01)
PURPOSE: To evaluate the transfer of heterologous genes carrying a Green Fluorescent Protein (GFP) reporter cassette to primary corneal epithelial cells ex vivo. METHODS: Freshly enucleated rabbit corneoscleral tissue was ...
The Dual Role of CCR5 in the Course of Influenza Infection: Exploring Treatment Opportunities
(Frontiers Media, 2022)
RUNX family: Oncogenes or tumor suppressors
(Facultad de Medicina y Ciencia, 2019)
Runt-related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs. In the last decade, the whole family has been implicated ...
The long non-coding RNA ANRASSF1 in the regulation of alternative protein-coding transcripts RASSF1A and RASSF1C in human breast cancer cells: implications to epigenetic therapy
(2019-08-03)
Alternative protein-coding transcripts of the RASSF1 gene have been associated with dual functions in human cancer: while RASSF1C isoform has oncogenic properties, RASSF1A is a tumour suppressor frequently silenced by ...