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Structure-based drug design to overcome drug resistance: challenges and opportunities
(Bentham ScienceBussum, 2014-02)
Drug resistance is a common concern for the development of novel antiviral, antimicrobial and anticancer therapies. To overcome this problem, several strategies have been developed, many of which involving the theme of ...
Emerging strategies on in silico drug development against COVID-19: challenges and opportunities
The importance of coronaviruses as human pathogen has been highlighted by the recent
outbreak of SARS-CoV-2 leading to the search of suitable drugs to overcome respiratory
infections caused by the virus. Due to the lack ...
Molecular docking and drug discovery in β-adrenergic receptors
(Bentham Science Publishers B.V., 2017)
Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence
(Frontiers Media, 2021)
New approaches in antimalarial drug discovery and development - A Review
(Fundação Oswaldo Cruz, 2014)
Recent insights for the emerging COVID-19: drug discovery, therapeutic options and vaccine development
SARS-CoV-2 has been marked as a highly pathogenic coronavirus of COVID-19
disease into the human population, causing over 5.5 million confirmed cases
worldwide. As COVID-19 has posed a global threat with significant human ...
Recent advances in the discovery of small molecules targeting glioblastoma
(2019-02-15)
Glioblastoma (GBM) is one of the most common central nervous system cancers. It is characterized as a fast-growing tumor that arises from multiple cell types with neural stem-cell-like properties. Additionally, GBM tumors ...
In silico modeling of FDA-approved drugs for discovery of therapies against neglected diseases: A drug repurposing approach
(Elsevier, 2019)
Drug repurposing (i.e., finding new therapeutic uses for already known drugs, including approved, abandoned, discontinued, and investigational drugs) is being extensively applied worldwide to expedite the development of ...
Folate biosynthesis pathway: mechanisms and insights into drug design for infectious diseases
(Future Sci Ltd, 2018-04-01)
Folate pathway is a key target for the development of new drugs against infectious diseases since the discovery of sulfa drugs and trimethoprim. The knowledge about this pathway has increased in the last years and the ...