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Synthesis, cytotoxicity and in vitro antileishmanial activity of naphthothiazoles
(2013-06-01)
The leishmaniasis is a spectral disease caused by the protozoan Leishmania spp., which threatens millions of people worldwide. Current treatments exhibit high toxicity, and there is no vaccine available. The need for new ...
Optimal drug infusion profiles using a Particle Swarm Optimization algorithm
(Elsevier, 2015-11)
The dynamic optimization of the administration of therapeutic drugs in simulated patients is proposed. The approach is based on a non-linear discontinuous cardiorespiratory model, which has been conceived to simulate the ...
Selected aspects of the chemical and biological profile of triclabendazole: A widely used benzimidazole fasciolicidal agent
(Nova Science Publishers, 2019)
Fasciolosis is a very serious parasiticdisease, caused by Fasciola hepaticaand Fasciola gigantica, which isresponsible for heavy economic losses in the production of sheep and cattle inmany countries around the world. In ...
CYP450 Metabolism of a Semisynthetic Naphthoquinone, an Anticancer Drug Candidate, by Human Liver Microsomes
(Soc Brasileira Quimica, 2022-02-21)
CNFD (6b,7-dihydro-5H-cyclopenta[b]naphtho[2,1-d]furan-5,6(9aH)-dione) is a semisynthetic naphthoquinone derived from lawsone that has cytotoxic action in different tumor lines and anticancer activity in vivo. Therefore, ...
Assessment of the chemical profile, polyphenol content and antioxidant activity in extracts of Psidium Guajava L. fruits
(2012-12-13)
Fruits and vegetables that are rich in polyphenolic compounds, especially flavonoids, may be used to benefit human health by reducing the incidence of cancers and cardiovascular diseases. Previous studies have demonstrated ...
Assessment of the chemical profile, polyphenol content and antioxidant activity in extracts of Psidium Guajava L. fruits
(2012-12-13)
Fruits and vegetables that are rich in polyphenolic compounds, especially flavonoids, may be used to benefit human health by reducing the incidence of cancers and cardiovascular diseases. Previous studies have demonstrated ...