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Cardiovascular drugs inducing QT prolongation: facts and evidence
(Bentham Science Publishers, 2010-01)
Acquired QT syndrome is mainly caused by the administration of drugs that prolong ventricular repolarization. On the other hand, the risk of drug-induced torsades de pointes is increased by numerous predisposing factors, ...
Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk
(RPIC, 2021)
The detection of proarrhythmic side effects in many marketed drugs has prompted the search for complementary non-invasive markers of cardiotoxicity risk. Novel indices based on the study of cardiac vector dynamics have now ...
Biomarkers of pre-existing risk of Torsade de Pointes under Sotalol treatment
(Elsevier, 2020-05)
Introduction: Antiarrhythmic drugs therapies are currently going through a turning point. The high risk that exists during the treatments has led to an ongoing search for new non-invasive toxicity risk biomarkers. Methods: ...
Cardiotoxicidad inducida por fármacos: síndrome de QT prolongado con potencial arritmogénico
(Sociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la Salud, 2020-03-16)
Safety limits of antidepressant use plus combinations: Focus on cardiovascular function
(2018-01-01)
Background: Antidepressants have been widely prescribed for depression, anxiety, sleep disorders, and in the management of behavioural symptoms of adult-old patients. Although generally safe, newer generation antidepressants ...
Uso de medicamentos e prolongamento do intervalo QTc em uma Unidade de Terapia Intensiva adulto
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS FARMACÊUTICAS, 2017-05-31)
Introduction: Medication-induced long QT syndrome (LQTS) can lead to Torsade de Pointes (TdP), a rare polymorphic ventricular tachycardia that can be fatal. Objectives: To investigate the QTc interval prolongation in ...
Reacciones adversas reportadas por metadona al programa Mundial de farmacovigilancia de la Organización Mundial de la Salud (OMS) entre los años 1968-2019
(Bogotá : Universidad de Ciencias Aplicadas y Ambientales, 2019Facultad de CienciasQuímica Farmacéutica, 2019)
Reacciones y usos similares a los de la morfina. Así mismo, se utiliza en el tratamiento de la drogodependencia, pero su uso es limitado en algunos países a pesar de la prevalencia considerable del uso indebido de heroína. ...
Identificación de mutaciones en genes asociados a canalopatías hereditarias mediante análisis exómico
(Universidad Nacional de ColombiaBogotá - Ciencias - Doctorado en Ciencias - BiologíaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá, 2023-05-31)
El estudio de muerte súbita cardiaca es muy importante, dada la alta incidencia a nivel mundial, y en los países industrializados se ha convertido un problema de salud pública. Sin embargo, el abordaje de este tipo de ...