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Deregulation of Mitochondria-Shaping Proteins Opa-1 and Drp-1 Plays a Decisive Role in Manganese-Induced Apoptosis
(Public Library Of Science, 2014-03)
Mitochondria are dynamic organelles that undergo fusion and fission processes. These events are regulated by mitochondria-shaping proteins. Changes in the expression and/or localization of these proteins lead to a ...
Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction
(Wiley-BlackwellOxford, 2013-10-08)
BACKGROUND:
Ischemia and reperfusion (IR) injury remains a major cause of morbidity and mortality and multiple molecular and cellular pathways have been implicated in this injury. We determined whether acute inhibition ...
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death
(Wiley-VCH Verlag, 2014)
Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury
(Lippincott Williams and Wilkins, 2014)
Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway
(Company of Biologists Ltd, 2014)
Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism. Mitochondria are crucial organelles for the production of ATP, and their morphology and function are regulated by the dynamic processes ...
Regulación de la dinámica y metabolismo mitocondrial por incretina GLP-1 en células de la línea A7r5
(Universidad de Chile, 2014)
El péptido similar a glucagón-1 (GLP-1) es una incretina secretada por las células intestinales. Su acción clásica es regular la respuesta secretoria de insulina por el páncreas. Sin embargo, recientemente se ha descrito ...
Regulación de la dinámica mitocondrial del cardiomiocito por igf-1 y norepinefrina
(Universidad de Chile, 2012)
La hipertrofia cardíaca es una respuesta adaptativa desencadenada por una mayor
demanda de trabajo contráctil por parte del cardiomiocito, su desarrollo es el resultado
de múltiples factores, existiendo una hipertrofia ...
Regulación de la respuesta a insulina por ceramidas en el cardiomiocito a nivel de la dinámica mitocondrial
(Universidad de Chile, 2012)
La obesidad y la diabetes son condiciones altamente prevalentes que representan un importante factor de riesgo para el desarrollo de patologías cardiovasculares, principal causa de muerte entre los pacientes diabéticos. ...