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Effect of doxorubicin on cardiac lipid metabolism-related transcriptome and the protective activity of Alda-1
(Elsevier B.V., 2021-05-05)
The use of doxorubicin (DOX) as an antineoplastic drug is compromised by its cardiotoxicity risk. Although several mechanisms have been proposed for DOX-induced cardiac dysfunction, there is still increased interest in ...
Biocompatible Microemulsion Modifies the Tissue Distribution of Doxorubicin
(Wiley-Blackwell, 2014-10-01)
The incorporation of doxorubicin (DOX) in a microemulsion (DOX-ME) has shown beneficial consequences by reducing the cardiotoxic effects of DOX. The aim of this study was to determine the distribution of DOX-ME in Ehrlich ...
Efeito do adoçante à base de sucralose em modelo experimental de cardiotoxicidade aguda induzida pela doxorrubicina
(Universidade Estadual Paulista (Unesp), 2021-02-26)
INTRODUÇÃO: Apesar de a doxorrubicina (DOX) ser um dos fármacos antitumorais mais utilizados e eficientes, apresenta diversos efeitos colaterais, sendo a cardiotoxicidade a preocupação mais importante dos oncologistas no ...
Avaliação da biodistribuição e da toxicidade aguda in vivo de lipossomas pH-sensíveis de circulação prolongada contendo doxorrubicina
(Universidade Federal de Minas GeraisUFMG, 2016-08-01)
Doxorubicin (DOX) is an anthracyclic antineoplastic agent widely used on control of solid tumors, however, severe side effects of this drug, especially severe and sometimes irreversible cardiotoxicity, has limited the DOX ...
Nanocápsulas de selol com invólucro de poli(metil vinil-éter co-anidrido maléico) conjugado à doxorrubicina : desenvolvimento e avaliação de seu potencial anticâncer in vitro e in vivo
(2016-03-30)
A doxorrubicina (DOX) tem se mostrado eficaz no tratamento de cânceres sólidos e hematológicos, mas a sua potencial cardiotoxicidade irreversível, limita o sucesso do tratamento, levando a um baixo índice terapêutico. O ...
Effects of pamidronate in acute cardiotoxicity induced by doxorubicin in rats
(2015)
Aim: Evaluate pamidronate (Pam) effects in ventricular function, matrix metalloproteinase-2 (MMP-2) activity, oxidative stress, and myocardial energetic metabolism during acute doxorubicin (Dox)-induced cardiotoxicity. ...
Protonation Pattern, Tautomerism, Conformerism, and Physicochemical Analysis in New Crystal Forms of the Antibiotic Doxycycline
(Amer Chemical Soc, 2014-08-01)
Doxycycline (DOX) is a tetracycline class drug that is used worldwide as a broad-spectrum antibiotic. Although its clinical importance and use have been known since the 1960s, only four crystal forms have been reported ...
Carreadores lipídicos nanoestruturados contendo doxorrubicina, ácido docosahexaenóico e succinato de α-tocoferol: formulação, caracterização e avaliação do potencial terapêutico contra o câncer.
(Universidade Federal de Minas GeraisBrasilFARMACIA - FACULDADE DE FARMACIAPrograma de Pós-Graduação em Ciências FarmacêuticasUFMG, 2021-09-09)
Encapsulation of doxorubicin (DOX) in nanocarriers has been proposed to overcome
its limitations. In this work, a nanostructured lipid carriers (NLC) formulation
containing DOX and the anticancer adjuvants docosahexaenoic ...
Systemic and local effects of doxycycline and low-intensity laser treatment on periodontitis in rats
(2021-01-01)
Purpose: This study evaluated the systemic and local effects of doxycycline (DOX) and lowintensity laser (LIL) treatment as adjuvants to scaling and root planing (SRP) in the treatment of experimental periodontitis in rats. ...
Doxorubicin nanoformulations on therapy against cancer: An overview from the last 10 years
(2022-01-01)
Doxorubicin (DOX) is a natural antibiotic with antineoplastic activity. It has been used for over 40 years and remains one of the most used drugs in chemotherapy for a variety of cancers. However, cardiotoxicity limits its ...