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Lycopene up-regulates mRNA expressions of SIRT and adiponectin and down-regulates PPAR(gamma) and IL-6 in adipose tissue of hypercaloric diet-fed rats
(Federation Amer Soc Exp Biol, 2013-04-01)
Iron accumulation induce Nurr1 down-regulation and dopaminergic neurodegeneration in a model of Parlkinson's disease
(2015)
sustantia nigra pars compact, main brain nuclei affected with this disease. Iron has been
reported that acts as a catalyst for the production of hydroxyl radicals and as a regulator
of the expression of α-synuclein. Nurr1, ...
Down-regulation of NF-κB signaling by Gordonia bronchialis prevents the activation of gut epithelial cells
(Sage Publications Ltd, 2014-08)
The immunomodulatory power of heat-killed Gordonia bronchialis was studied on gut epithelial cells activated with pro-inflammatory stimuli (flagellin, TNF-α or IL-1β). Light emission of luciferase-transfected epithelial ...
Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice
(Wiley, 2013)
The liver-derived peptide hepcidin controls the balance between iron demand and iron supply. By inhibiting the iron export activity of ferroportin, hepcidin modulates iron absorption and delivery from the body's stores. ...
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death
(Wiley-VCH Verlag, 2014)