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Oxidation of Hantzsch 1,4-dihydropyridines of pharmacological significance by electrogenerated superoxide
(KLUWER ACADEMIC/PLENUM PUBL, 2004-03)
The final pyridine derivatives were separated and identified by gas chromatography/ mass spectrometry (GC-MS). The intermediates, anion dihydropyridine and the HO2./HO2- species, were observed from voltammetric studies and ...
1,4-Dihydropyridines: Reactivity of nitrosoaryl and nitroaryl derivatives with alkylperoxyl radicals and ABTS radical cation
(TAYLOR & FRANCIS, 2004-07)
In the present paper, a direct quenching of radical species by a number of synthesized nitrosoaryl 1,4-dihydropyridines and their parent nitroaryl 1,4-dihydropyridines was determined in aqueous media at pH 7.4. These two ...
Unexpected diastereotopic behaviour in the H-1 NMR spectrum of 1,4-dihydropyridine derivatives triggered by chiral and prochiral centres
(SOC BRASILEIRA QUIMICA, 2005-01)
1,4-dihydropyridine derivatives constitute an important pharmacological group for the treatment of cardiovascular diseases. We have synthesised a series 4-(5'-nitro-2'-furyl)-1,4-dihydropyridine derivatives, which were ...
Voltammetric behavior of 1,4‐dihydropyridine calcium antagonists
(1994)
The anodic electrochemical behavior of the five members of the 1,4‐dihydropyridine calcium antagonists family was studied. In all of the studied compounds (nifedipine, nitrendipine, nimodipine, nicardipine, and furaldipine), ...
Nitroaryl-1,4-dihydropyridines as antioxidants against rat liver microsomes oxidation induced by iron/ascorbate, Nitrofurantoin and naphthalene
(PERGAMON-ELSEVIER SCIENCE LTD, 2007)
1,4-Dihydropyridines (DHPs) used in the treatment of cardiovascular diseases, are calcium channel antagonists and also antioxidant agents. These drugs are metabolized through cytochrome P-450 oxidative system, majority ...
Synthesis and electrochemical oxidation of hybrid compounds:dihydropyridine-fused coumarins
(Elsevier, 2013)
tIn this paper, a series of six dihydropyridine-fused coumarins were synthesized and electrochemicallycharacterized in dimethylformamide (DMF).Dihydropyridine ring oxidation on glassy carbon electrode (GCE) for condensed ...
Synthesis and electrochemical oxidation of hybrid compounds: Dihydropyridine-fused coumarins
(2014)
In this paper, a series of six dihydropyridine-fused coumarins were synthesized and electrochemically characterized in dimethylformamide (DMF). Dihydropyridine ring oxidation on glassy carbon electrode (GCE) for condensed ...
Unexpected diastereotopic behaviour in the 1H NMR spectrum of 1,4-dihydropyridine derivatives triggered by chiral and prochiral centres
(2005)
1,4-dihydropyridine derivatives constitute an important pharmacological group for the treatment of cardiovascular diseases. We have synthesised a series 4-(5′-nitro-2′-furyl)-1,4-dihydropyridine derivatives, which were ...
Structural effects on the reactivity 1,4-dihydropyridines with alkylperoxyl radicals and ABTS radical cation
(PERGAMON-ELSEVIER SCIENCE, 2004-05-01)
A series of eight commercial C-4 substituted 1,4-dihydropyridines and other synthesized related compounds were tested for direct potential scavenger effect towards alkylperoxyl radicals and ABTS radical cation in aqueous ...