The 1,3-dipolar cycloadditions of bis(diisopropylamino)phosphinodiazomethane, 10, to chiral electron-deficient olefins have been investigated for the first time. The results have been compared with those corresponding to ...

1. A new procedure was developed for the isolation of bothropain from Bothrops jararaca plasma. the previously used proteolytic digestion step was abolished and HPLC was introduced for the final purification.2. Comparison ...

The synthesis of new indazol-4,7-dione derivatives via 1,3-dipolar cycloaddition of diazomethane with 2,3-dimethyl-1,4-benzoquinone (2) and 1,4-naphthoquinone (7) followed by N-alkylation of the pyrazol nitrogen atom of ...

Peptidyl diazomethane (PDAM) derivatives, a class of irreversible inhibitors for cysteine proteinase, were screened for the ability to impair Trypanosoma cruzi invasion and intracellular development in primary cultures of ...

Hexane extracts were obtained from the fruits and stems of Pistacia mexicana, from which β-sitosterol (1) and masticadienonic acid (2) were isolated, obtaining the latter in significant quantities. Using 2 as starting ...