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Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis

Universidade Estadual de Campinas (UNICAMP); Universidade Federal de Pernambuco (UFPE); Universidade Estadual Paulista (Unesp) (2018-05-09)

Background: Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. ...

Physicochemical characterization and improved in vitro dissolution performance of diacerein solid dispersions with PVP K30

Patil, Snehal B.; Shete, Tushar K.; Narade, Sarika B.; Surve, Sharda S.; Khan, Ziya K.; Bhokare, Kuldeep K.; Pore, Yogesh V. (2011)

Efeito da diacereína sobre a febre induzida por suspensão de Saccharomyces cerevisiae e por prostaglandina e2 em ratos jovens

Pasin, Juliana Saibt Martins (Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2005-06-10)

Fever is a systemic response that results of a cascade of events that usually begins with pathogenic infection. Its development represents an important aspect of host defense that is mediated by the central nervous system. ...

Diacerein: A potential multi-target therapeutic drug for COVID-19

Gonçalves de Oliveira, Pedro; Termini, Lara; Durigon, Edison Luiz; Lepique, Ana Paula; Sposito, Andrei C; Boccardo, Enrique

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 19 (COVID19), was declared pandemic by the World Health Organization in March 2020. SARS-CoV-2 binds its host cell receptor, ...

Effect of oral diacerein (DAR) in an experimental hip chondrolysis model

Kitadai, Humberto Ken [UNIFESP]; Takahashi, Helio Kiyoshi [UNIFESP]; Straus, Anita Hilda [UNIFESP]; Ibanez, J. F.; Lucas, R.; Kitadai, Fabio Takashi [UNIFESP]; Milani, Carlo [UNIFESP] (Wiley-Blackwell, 2006-06-01)

We aimed to reproduce the articular cartilage structural changes in a joint exposed to a metallic implant as in the adolescent pinned hip with persistent joint penetration and secondly, to test the effect of an interleukin ...

Diacerein for osteoarthritis

Fidelix, Tania Sales de Alencar [UNIFESP]; Macedo, Cristiane Rufino de [UNIFESP]; Maxwell, Lara J.; Trevisani, Virgínia Fernandes Moça [UNIFESP] (Wiley-Blackwell, 2014-01-01)

BackgroundOsteoarthritis (OA) is one of the most prevalent musculoskeletal diseases. There is currently no consensus on what is the best treatment to improve OA symptoms and slow disease progression. Diacerein is an ...

Diacerein-induced interleukin-1β deficiency reduces the inflammatory infiltrate and immunoexpression of matrix metalloproteinase-8 in periodontitis in rat molars

Universidade Estadual Paulista (UNESP) (2022-01-01)

Background: Periodontitis is an immunoinflammatory disease that involves the release of cytokines and enzymes, including interleukin-1 (IL-1) and matrix metalloproteinases (MMPs). Diacerein is an anti-IL-1 drug used for ...

Diacerein Improves Left Ventricular Remodeling And Cardiac Function By Reducing The Inflammatory Response After Myocardial Infarction

Torina; Anali Galluce; Reichert; Karla; Lima; Fany; de Souza Vilarinho; Karlos Alexandre; Martins de Oliveira; Pedro Paulo; Pereira do Carmo; Helison Rafael; de Carvalho; Daniela Diogenes; Abdalla Saad; Mario Jose; Sposito; Andrei Carvalho; Petrucci; Orlando (PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2015)

Ação da diacereína no remodelamento ventricular esquerdo após infarto agudo do miocárdio = estudo experimental = The diacerein properties on the left ventricle remodeling after acute myocardial infarction: experimental studyThe diacerein properties on the left ventricle remodeling after acute myocardial infarction : experimental study

Torina, Anali Galluce, 1981- ([s.n.], 2016)

Diacerein Improves Left Ventricular Remodeling And Cardiac Function By Reducing The Inflammatory Response After Myocardial Infarction.

Torina, Anali Galluce; Reichert, Karla; Lima, Fany; de Souza Vilarinho, Karlos Alexandre; de Oliveira, Pedro Paulo Martins; do Carmo, Helison Rafael Pereira; de Carvalho, Daniela Diógenes; Saad, Mário José Abdalla; Sposito, Andrei Carvalho; Petrucci, Orlando (2015)