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Quantification of carvedilol in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry - Application to bioequivalence study
(Elsevier Science BvAmsterdamHolanda, 2005)
Enantioselective analysis of zopiclone and its metabolites in plasma by liquid chromatography/tandem mass spectrometry
(SPRINGER HEIDELBERG, 2011)
A high-performance liquid chromatographic method with triple-quadrupole mass spectrometry detection (LC-MS-MS) was developed and validated for the first time for the simultaneous quantification of zopiclone and its metabolites ...
In vitro characterization of rosiglitazone metabolites and determination of the kinetic parameters employing rat liver microsomal fraction
(SPRINGER FRANCE, 2011)
Rosiglitazone (RSG), a thiazolidinedione antidiabetic drug, is metabolized by CYP450 enzymes into two main metabolites: N-desmethyl rosiglitazone (N-Dm-R) and rho-hydroxy rosiglitazone (rho-OH-R). In humans, CYP2C8 appears ...
Assessment of Vascular Effects of Tamoxifen and Its Metabolites on the Rat Perfused Hindquarter Vascular Bed
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Tamoxifen has been suggested to produce beneficial cardiovascular effects, although the mechanisms for these effects are not fully known. Moreover, although tamoxifen metabolites may exhibit 30-100 times higher potency ...
Simultaneous determination of rosiglitazone and its metabolites in rat liver microsomal fraction using hollow-fiber liquid-phase microextraction for sample preparation
(WILEY-V C H VERLAG GMBH, 2010)
A three-phase hollow-fiber liquid-phase microextraction method for the analysis of rosiglitazone and its metabolites N-desmethyl rosiglitazone and p-hydroxy rosiglitazone in microsomal preparations is described for the ...
Oxidation of lysergic acid diethylamide (LSD) by peroxidases: a new metabolic pathway
(SPRINGERNEW YORK, 2012)
Lysergic acid diethylamide (LSD) is a potent hallucinogen that is primarily metabolized to 2-oxo-3-hydroxy-LSD (O-H-LSD) and N-desmethyl-LSD (nor-LSD) by cytochrome P450 complex liver enzymes. Due to its extensive metabolism, ...
Metoprolol induces oxidative damage in common carp (Cyprinus carpio)
(Aquatic Toxicology, 2018)