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Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor
(Wiley, 2020)
Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle-specific E3 ligases, atrogin-1 and MuRF-1, and ...
Effect of cholic bile acid and deoxycholic acid through TGR5 receptor on skeletal muscle atrophy and mitochondrial dysfunction in the skeletal muscle.
(2020)
The skeletal muscle atrophy consists in muscle mass loss and decreased force generation, produced by molecular mechanisms such as oxidative stress and imbalance in synthesis/degradation proteins processes, that generates ...
Concentration-dependent effects of sodium cholate and deoxycholate bile salts on breast cancer cells proliferation and survival
(Springer, 2020-04)
Bile acids (BAs) are bioactive molecules that have potential therapeutic interest and their derived salts are used in several pharmaceutical systems. BAs have been associated with tumorigenesis of several tissues including ...
Lipase-Catalyzed Acetylation and Esterification of Bile Acids
(Humana Press, 2018)
In this chapter we describe the application of lipases as catalysts in reactions on a relevant family of steroids: the bile acids. Twenty three mono-, diacetyl and ester derivatives of deoxycholic-, chenodeoxycholic-, ...
Preparación y caracterización de nanopartículas de quitosano modificado para la encapsulación de polifenoles con potencial aplicación en el tratamiento de leucemia
(Ciencia de los MaterialesMedellín, Colombia, 2023)
Enzymatic synthesis of bile acid derivatives and biological evaluation against Trypanosoma cruzi
(Elsevier, 2015-05-30)
Enzyme catalysis was applied to synthesize derivatives of three bile acids and their biological activity was evaluated as growth inhibitors of the protozoan Trypanosoma cruzi. Twelve mono-, diacetyl and ester derivatives ...
Isolation of acetylated bile acids from the sponge Siphonochalina fortis and DNA damage evaluation by the comet assay
(Elsevier, 2013-10)
From the organic extracts of the sponge Siphonochalina fortis, collected at Bahía Bustamante, Chubut, Argentina, three major compounds were isolated and identified as deoxycholic acid 3, 12-diacetate (1), cholic acid 3, ...
Bile acids induce alterations in mitochondrial function in skeletal muscle fibers
(MDPI, 2022)
Cholestatic chronic liver disease is characterized by developing sarcopenia and elevated serum levels of bile acids. Sarcopenia is a skeletal muscle disorder with the hallmarks of muscle weakness, muscle mass loss, and ...