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Effect of bile acid on the cell membrane functionality of lactic acid bacteria for oral administration
(Elsevier Science, 2006-10)
Lactic acid bacteria and other species dwelling in the gut must be tolerant to bile salts. This study sought to determine the effects of the bile salts taurodeoxycholate (TDCA) and deoxycholate (DCA) on Lactobacillus reuteri ...
Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor
(Wiley, 2020)
Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle-specific E3 ligases, atrogin-1 and MuRF-1, and ...
Oxidative stress, antioxidants and intestinal calcium absorption
(W J G Press, 2017-04)
The disequilibrium between the production of reactive oxygen (ROS) and nitrogen (RNS) species and their elimination by protective mechanisms leads to oxidative stress. Mitochondria are the main source of ROS as by-products ...
Effect of cholic bile acid and deoxycholic acid through TGR5 receptor on skeletal muscle atrophy and mitochondrial dysfunction in the skeletal muscle.
(2020)
The skeletal muscle atrophy consists in muscle mass loss and decreased force generation, produced by molecular mechanisms such as oxidative stress and imbalance in synthesis/degradation proteins processes, that generates ...