Pregabalin (PGB) is extensively prescribed to treat neurological andneuropsychiatrical conditions such as neuropathic pain, anxiety disorders and epilepsy.Although PGB is known to bind selectively to the α2δ subunit of ...

New neurons are continuously added throughout life to the dentate gyrus of the mammalian hippocampus. During embryonic and early postnatal development, the dentate gyrus is formed in an outside-in layering pattern that may ...

Dentate granule cells are generally considered to be relatively resistant to excitotoxicity and have been associated with robust synaptogenesis after neuronal damage. Synaptic reorganization of dentate granule cell axons, ...

Throughout the adult life of all mammals including humans, new neurons are incorporated to the dentate gyrus of the hippocampus. During a critical window that lasts about two weeks, adult-born immature neurons are more ...

The dentate gyrus of the hippocampus generates neurons throughout life, but adult neurogenesis exhibits a marked age-dependent decline. Although the decrease in the rate of neurogenesis has been extensively documented in ...

Neurogenesis in the dentate gyrus continues into adulthood, yet little is known about the function of newly born neurons or how they integrate into an existing network of mature neurons. We made transgenic mice that ...

The temporomandibular joints and associated muscles allow the mandible to move in the three planes (sagittal, frontal and horizontal), in this way the jaw can perform complex mandibular movements. For several decades, ...

Memory systems ought to store and discriminate representations of similar experiences in order to efficiently guide future decisions. This problem is solved by pattern separation, implemented in the dentate gyrus (DG) by ...

Cell loss in the hippocampal formation is a common event in patients with temporal lobe epilepsy. the belief that dentate granule neurons are relatively resistant to excitotoxic injury has recently been challenged both, ...