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The conversion of dehydroepiandrosterone into androst-5-ene-3β, 17β-diol (androstenediol) is increased in endometria from untreated women with polycystic ovarian syndrome
(2010)
The changes in endometrial homeostasis found in women with polycystic ovarian syndrome (PCOS) could be associated with alterations in the intracrine metabolism of steroid hormones. The uptake of dehydroepiandrosterone-sulphate ...
Biotransformation of dehydro-epi-androsterone by Aspergillus parasiticus: Metabolic evidences of BVMO activity
(Elsevier Science Inc, 2016-05)
The research on the synthesis of steroids and its derivatives is of high interest due to their clinical applications. A particular focus is given to molecules bearing a D-ring lactone like testolactone because of its ...
Plant and animal steroids a new hope to search for antiviral agents
(Bentham Science Publishers, 2010-01)
Scientific literature provides evidence about the use of steroids as an adjunct treatment to antiviral therapies. Immunomodulatory activity of some steroids would account for the recovery in patients with herpetic and other ...
Inhibition of osteoblast function by Brucella abortus is reversed by dehydroepiandrosterone and involves ERK1/2 and estrogen receptor
(Frontiers Media S.A., 2018-01)
Brucella abortus induces an inflammatory response that stimulates the endocrine system resulting in the secretion of cortisol and dehydroepiandrosterone (DHEA). Osteoarticular brucellosis is the most common presentation ...
Anti-adenovirus activity of epiandrosterone and dehydroepiandrosterone derivatives
(Karger, 2010-05)
Background: Dehydroepiandrosterone (DHEA) exhibits a wide range of biological functions including antiviral activity. In this work, we present in vitro anti-adenovirus (AdV) activity of seven DHEA and twelve epiandrosterone ...
Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Dehydroepiandrosterone ( DHEA) is known as an intermediate in the synthesis of mammalian steroids and a potent uncompetitive inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH), but not the enzyme from plants ...
Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome
(Elsevier, 2010-04)
During the last decade a battery of animal models used for the study of polycystic ovary syndrome (PCOS) have allowed a focus on different aspects of the pathology. Since dehydroepiandrosterone (DHEA) was found to be one ...
Modulation of the phenotype and function of Mycobacterium tuberculosis-stimulated dendritic cells by adrenal steroids
(Oxford University Press, 2013-02)
Cell-mediated immunity, cytokines induced during the specific immune response and T-cell populations are crucial factors for containing Mycobacterium tuberculosis infection. Recent reports suggest a cross-regulation between ...