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Assays to Assess Autophagy Induction and Fusion of Autophagic Vacuoles with a Degradative Compartment, Using Monodansylcadaverine (MDC) and DQ-BSA
(Elsevier Academic Press Inc., 2009-12)
In this chapter we describe the use of monodasylcadaverine (MDC) and DQ-BSA, two practical and convenient tools to study the autophagic pathway. MDC is a lysosomotropic compound useful for the identification of autophagic ...
Sensitization to gliadin induces moderate enteropathy and insulitis in nonobese Diabetic-DQ8 mice
(American Association of Immunologists, 2011-10)
Celiac Disease (CD) is frequently diagnosed in patients with type 1 diabetes (T1D), and T1D patients can exhibit antibodies against tissue transglutaminase, the auto-antigen in CD. Thus, gliadin, the trigger in CD, has ...
Vacúolos parasitóforos induzidos porLeishmania amazonensis e Leishmania major interagem de forma distintacom a via autofágica
(Centro de Pesquisas Gonçalo Moniz, 2014)
Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation
(Wiley Blackwell Publishing, Inc, 2016-11)
Endocytosis is a multistep process engaged in extracellular molecules internalization. Several proteins including the Rab GTPases family coordinate the endocytic pathway. The small GTPase Rab7 is present in late endosome ...
Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation.
(Wiley, 2016)
Endocytosis is a multistep process engaged in extracellular molecules internalization. Several proteins including the Rab GTPases family coordinate the endocytic pathway. The small GTPase Rab7 is present in late endosome ...
Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation.
(Wiley, 2016)
Endocytosis is a multistep process engaged in extracellular molecules internalization. Several proteins including the Rab GTPases family coordinate the endocytic pathway. The small GTPase Rab7 is present in late endosome ...
Applications of NMR techniques: Hyphenations (LC-SPENMR), affinity (DOSY) and NOE based (STD and Tr-OESY) to probe the binding interactions of ligands (synthetic and natural) towards protein
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Química - PPGQ, 2014-01-17)
O foco principal desse trabalho foi a implementação, otimização e aplicações práticas de métodos de ressonância magnética nuclear (RMN) com o propósito de avaliar as interações entre moléculas de diferentes massas molares, ...
Autophagic induction Greatly Enhances Leishmania major intracellular survival compared to Leishmania amazonensis in CBA/j-infected macrophages
(Frontiers Research Foundation, 2018-08)
CBA mouse macrophages control Leishmania major infection yet are permissive to Leishmania amazonensis. Few studies have been conducted to assess the role played by autophagy in Leishmania infection. Therefore, we assessed ...
Inhibition of Poly(ADP-Ribose)Glycohydrolase activity affects lysosomal function and hampers T. cruzi infection in Vero cells
(Genetics Society of America, 2020)
Chagas disease is a potentially life-threatening protozoan infection but, despite its high incidence and large economic costs associated to it, effective pharmacological treatments are lacking. The search for new anti-chagasic ...