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Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
(Wiley Blackwell Publishing, Inc, 2008-07)
Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific ...
Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice
(Springer, 2000-10)
Rationale: Dopamine D2 receptors are postulated to play an important role in modulating the reinforcing effects of abused drugs including ethanol. Objectives: This experiment examined operant ethanol self-administration ...
Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors
(Wiley-liss, Div John Wiley & Sons Inc, 2009-11)
The dopamine D4 receptor (D4R) is predominantly expressed in the prefrontal cortex, a brain area that integrates motor, rewarding, and cognitive information. Because participation of D4Rs in executive learning is largely ...
Absence of dopamine D4 receptors results in enhanced reactivity to unconditioned, but not conditioned, fear
(Wiley Blackwell Publishing, Inc, 2002-01)
The prefrontal cortex receives a major dopaminergic input from the ventral tegmental area, which plays an important role in the integration of neuronal signals influencing behavioural responses to stressful environmental ...
Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice
(Lippincott Williams, 2001-09)
Polymorphism of the dopamine receptor type-2 (D2) gene is associated with essential hypertension. To assess whether D2 receptors participate in regulation of blood pressure (BP), we studied mice in which the D2 receptor ...
The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
(Wiley Blackwell Publishing, Inc, 2001-03)
According to the dual systems model for opiate reward, dopamine mediates opiate motivation when an animal is in a deprived motivational state (i.e. opiate-dependent and in withdrawal) and not when an animal is in a nondeprived ...
Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice
(Pergamon-Elsevier Science Ltd, 2000-12)
Pharmacological blockade studies have supported a role of the dopamine system in ethanol reward for many years, but receptor subtype specificity has been difficult to establish. Recently, genetically engineered mice lacking ...
Failure of Intravenous Morphine to Serve as an Effective Instrumental Reinforcer in Dopamine D2 Receptor Knock-Out Mice
(Society for Neuroscience, 2002-05)
The rewarding effects of opiates are thought to be mediated through dopaminergic mechanisms in the ventral tegmental area, dopamine-independent mechanisms in the nucleus accumbens, or both. The purpose of the present study ...
Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"
(Elsevier, 2001-10)
Phenotypes were assessed topographically in mice lacking functional D2 dopamine receptors [‘knockouts’], using an ethologically based approach to assess all behaviours in the natural repertoire. D2-null mice evidenced an ...