Buscar
Mostrando ítems 1-10 de 253
Molecular and functional characteristics of DNA polymerase beta-like enzymes from trypanosomatids
(Frontiers Media, 2021)
Trypanosomatids are a group of primitive unicellular eukaryotes that can cause diseases in plants, insects, animals, and humans. Kinetoplast genome integrity is key to trypanosomatid cell survival and viability. Kinetoplast ...
Biochemical studies with DNA polymerase beta and DNA polymerase beta-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance
(Elsevier B.V., 2008-11-01)
Mammalian DNA polymerase p is a nuclear enzyme involved in the base excision and single-stranded DNA break repair pathways. in trypanosomatids, this protein does not have a defined cellular localization, and its function ...
Endogenous overexpression of an active phosphorylated form of DNA polymerase beta under oxidative stress in Trypanosoma cruzi
(Public Library Science, 2018)
Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and mitochondria ...
Expression, purification, and biochemical characterization of recombinant DNA polymerase beta of the Trypanosoma cruzi TcI lineage: requirement of additional factors and detection of phosphorylation of the native form
(Springer, 2015)
Chagas disease, caused by the protozoan
Trypanosoma cruzi, is a major parasitic disease that affects
millions of people in America. However, despite the high
impact of this disease on human health, no effective and ...
Determination of neutral polymorphisms (frameworks) of the human beta globin gene in beta thalassaemias by PCR/DGGE
(1997-02-01)
Purpose: Considering the importance of type beta thalassaemias as hereditary syndromes of high significance in different populations of Mediterranean origin and, by extension, in the Brazilian population, the objective of ...
Determination of neutral polymorphisms (frameworks) of the human beta globin gene in beta thalassaemias by PCR/DGGE
(1997-02-01)
Purpose: Considering the importance of type beta thalassaemias as hereditary syndromes of high significance in different populations of Mediterranean origin and, by extension, in the Brazilian population, the objective of ...
Rat DNA polymerase beta substitutes the repairing activity of DNA polymerase I in the lethal effect of UV light
(2002)
The aim of this work was to search if the rat DNA polymerase beta can substitute the capability of DNA polymerase I to repair damage caused by the UV light in Escherichia coli. The oriC origin of replication from p?5 was ...