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Brazilian propolis as a source of novel DNA methyltransferase inhibitors: A computer-aided discovery and in vitro approaches.
(Amer Assoc Cancer Research, 2018-01-01)
Evaluation Of New Dna Methyltransferases Inhibitors In Aml
(SPRINGERNEW YORK, 2015)
Effects of propolis and phenolic acids on triple-negative breast cancer cell lines: Potential involvement of epigenetic mechanisms
(2020-03-02)
Triple-negative breast cancer is an aggressive disease frequently associated with resistance to chemotherapy. Evidence supports that small molecules showing DNA methyltransferase inhibitory activity (DNMTi) are important ...
DNMT1 Inhibitor Restores RUNX2 Expression and Mineralization in Periodontal Ligament Cells
(Mary Ann Liebert, Inc, 2021-03-22)
Periodontal ligament cells (PDLCs) have well documented osteogenic potential; however, this commitment can be highly heterogenous, limiting their applications in tissue regeneration. In this study, we use PDLC populations ...
Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity
(2017-01-01)
Radiation therapy is widely used to treat human malignancies, but many tumor types, including gliomas, exhibit significant radioresistance. Radiation therapy creates DNA double-strand breaks (DSBs), and DSB repair is linked ...