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Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi
(Nature Research, 2019)
Structure, function and evolution of the animal mitochondrial replicative DNA helicase
(Taylor & Francis Ltd, 2016-01-02)
The mitochondrial replicative DNA helicase is essential for animal mitochondrial DNA (mtDNA) maintenance. Deleterious mutations in the gene that encodes it cause mitochondrial dysfunction manifested in developmental delays, ...
Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi
(Nature, 2019-02)
DNA polymerase theta (Polθ), a member of the DNA polymerase family A, exhibits a polymerase C-terminal domain, a central domain, and an N-terminal helicase domain. Polθ plays important roles in DNA repair via its polymerase ...
Insights Into The Recq Helicase Mechanism Revealed By The Structure Of The Helicase Domain Of Human Recql5
(Oxford Univ PressOxford, 2017)
Animal Mitochondrial DNA Replication
(2016-01-01)
Recent advances in the field of mitochondrial DNA (mtDNA) replication highlight the diversity of both the mechanisms utilized and the structural and functional organization of the proteins at mtDNA replication fork, despite ...
Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase
(Oxford Univ Press, 2018-04-06)
Pathological conditions impairing functions of mitochondria often lead to compensatory upregulation of the mitochondrial DNA (mtDNA) replisome machinery, and the replicative DNA helicase appears to be a key factor in ...
Stimulation of Variant Forms of the Mitochondrial DNA Helicase Twinkle by the Mitochondrial Single-Stranded DNA-Binding Protein
(2021-01-01)
Defects in mitochondrial DNA (mtDNA) maintenance may lead to disturbances in mitochondrial homeostasis and energy production in eukaryotic cells, causing diseases. During mtDNA replication, the mitochondrial single-stranded ...
Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2
(Elsevier, 2017-12)
Srs2 is a superfamily 1 (SF1) helicase and antirecombinase that is required for genome integrity. However, the mechanisms that regulate Srs2 remain poorly understood. Here, we visualize Srs2 as it acts upon single-stranded ...