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Probing the binding of the coumarin drugs using peptide fragments of DNA gyrase B protein
(2005-05-01)
Bacterial DNA gyrase, has been identified as the target of several antibacterial agents, including the coumarin drugs. The coumarins inhibit the gyrase action by competitive binding to the ATP-binding site of DNA gyrase B ...
Probing the binding of the coumarin drugs using peptide fragments of DNA gyrase B protein
(2005-05-01)
Bacterial DNA gyrase, has been identified as the target of several antibacterial agents, including the coumarin drugs. The coumarins inhibit the gyrase action by competitive binding to the ATP-binding site of DNA gyrase B ...
A 4.2 kDa synthetic peptide as a potential probe to evaluate the antibacterial activity of coumarin drugs
(Wiley-Blackwell, 2004-09-01)
The coumarin antibiotics are potent inhibitors of DNA replication whose target is the enzyme DNA gyrase, an ATP-dependent bacterial type II topoisomerase. The coumarin drugs inhibit gyrase action by competitive binding to ...
A 4.2 kDa synthetic peptide as a potential probe to evaluate the antibacterial activity of coumarin drugs
(Wiley-Blackwell, 2004-09-01)
The coumarin antibiotics are potent inhibitors of DNA replication whose target is the enzyme DNA gyrase, an ATP-dependent bacterial type II topoisomerase. The coumarin drugs inhibit gyrase action by competitive binding to ...
Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases
(Pergamon-Elsevier B.V. Ltd, 2008-12-01)
The ccd toxin-antitoxin system of the F plasmid encodes CcdB, a protein that poisons the essential Escherichia coli DNA gyrase, unique type IIA topoisomerase able to introduce negative supercoils into DNA. Based on CcdB ...
Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases
(Pergamon-Elsevier B.V. Ltd, 2008-12-01)
The ccd toxin-antitoxin system of the F plasmid encodes CcdB, a protein that poisons the essential Escherichia coli DNA gyrase, unique type IIA topoisomerase able to introduce negative supercoils into DNA. Based on CcdB ...
Second-generation 4,5,6,7-tetrahydrobenzo[d]thiazoles as novel DNA gyrase inhibitors
(Future Medicine, 2020-02)
Aim: DNA gyrase and topoisomerase IV are essential bacterial enzymes, and in the fight against bacterial resistance, they are important targets for the development of novel antibacterial drugs. Results: Building from our ...
Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases
(Pergamon-Elsevier B.V. Ltd, 2014)