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Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
(Sociedade Brasileira de Química, 2010-01-01)
The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts ...
Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
(Sociedade Brasileira de Química, 2010-01-01)
The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts ...
Mass Spectrometric Analysis of a Cyclic 7,8-Butanoguanine Adduct of N-Nitrosopyrrolidine: Comparison to Other N-Nitrosopyrrolidine Adducts in Rat Hepatic DNA
(AMER CHEMICAL SOC, 2009)
The well established rat hepatocarcinogen N-nitrosopytrolidine (NPYR, 1) requires metabolic activation to DNA adducts to express its carcinogenic activity. Among the NPYR-DNA adducts that have been identified, the cyclic ...
2 '-Deoxyguanosine, 2 '-deoxycytidine, and 2 '-deoxyadenosine adducts resulting from the reaction of tetrahydrofuran with DNA bases
(Amer Chemical Soc, 2006-07-17)
A recent study showed that tetrahydrofuran (THF), a widely used solvent, is carcinogenic in experimental animals. Despite its carcinogenic activity, there is a paucity of information regarding cellular toxicity, biomolecular ...
Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
(Sociedade Brasileira de Química, 2014)
Identification of Sudan III-(deoxy)-guanosine adducts formed in situ in a reaction with no catalyst
(Taylor & Francis Ltd, 2013-10-01)
Incubation of guanosine and Sudan III induces the formation of a stable adduct, which may be identified using a spectrophotometric technique and mass spectroscopy. The high nucleophilicity of the C-8 position and its ...
Mutagenicity of heteroaromatic amines: Computational study on the influence of methyl substituents
(Elsevier Science Inc, 2016-09-28)
Quantum mechanical calculations were performed to elucidate the factors determining the variations in mutagenic activity within groups of isomeric heteroaromatic amines that differ in the position of methyl substituents. ...
Mutagenicity and DNA adduct formation of PAH, nitro-PAH, and oxy-PAH fractions of atmospheric particulate matter from Sao Paulo, Brazil
(ELSEVIER SCIENCE BV, 2008)
Urban particulate matter (UPM) contributes to lung cancer incidence. Here, we have studied the mutagenic activity and DNA adduct-forming ability of fractionated UPM extractable organic matter (EOM). UPM was collected with ...
Electrochemical evaluation of rhodium dimer-DNA interactions
(Elsevier Science BvAmsterdamHolanda, 2002)