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Paracoccidioidomycosis: No genetic damage in human peripheral blood cells of patients assessed by single-cell gel (comet) assay
(2007-07-01)
Paracoccidioidomycosis is a systemic fungal infection caused by Paracoccidioides brasiliensis. As infectious diseases can cause DNA damage, the authors aimed at analyzing DNA breakage in peripheral blood cells of patients ...
Paracoccidioidomycosis: No genetic damage in human peripheral blood cells of patients assessed by single-cell gel (comet) assay
(2007-07-01)
Paracoccidioidomycosis is a systemic fungal infection caused by Paracoccidioides brasiliensis. As infectious diseases can cause DNA damage, the authors aimed at analyzing DNA breakage in peripheral blood cells of patients ...
Human syndromes with genomic instability and multiprotein machines that repair DNA double-strand breaks
(2003)
The present report deals with the functional relationships among protein complexes which, when mutated, are responsible for four human syndromes displaying cancer proneness, and whose cells are deficient in DNA double-strand ...
Avaliação da atividade protetora do guaraná (Paullinia cupana var. sorbilis) em modelo de hepatoxicidade induzida por tetracloreto de carbono em ratos
(Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em Farmacologia, 2013-07-12)
The liver diseases represent a relevant health problem, affecting once an organ of great importance in homeostasis maintaining. The search for herbal hepatoprotective capacity has been increasing, mainly because of the ...
FBH1 mediates DNA double strand breakage and apoptosis in response to DNA replication stress
(Rockefeller Univ Press, 2013-01)
Proper resolution of stalled replication forks is essential for genome stability. Purification of FBH1, a UvrD DNA helicase, identified a physical interaction with replication protein A (RPA), the major cellular singlestranded ...
Novel properties of melanins include promotion of DNA strand breaks, impairment of repair, and reduced ability to damage DNA after quenching of singlet oxygen
(ELSEVIER SCIENCE INCNEW YORK, 2012)
Melanins have been associated with the development of melanoma and its resistance to photodynamic therapy (PDT). Singlet molecular oxygen (102), which is produced by ultraviolet A solar radiation and the PDT system, is ...
Chromosome sensitivity to bleomycin in G2 lymphocytes from Down syndrome patients
(1997-03-01)
Several studies have demonstrated that lymphocytes from patients with Down syndrome (DS) exhibit an increased frequency of chromosome aberrations when they are exposed to ionizing radiation or to chemicals at the G0 or G1 ...
DNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzi
(2007-07-01)
This study aimed to evaluate whether experimental Chagas disease in acute phase under benznidazole therapy can cause DNA damage in peripheral blood, liver, heart, and spleen cells or induce nitric oxide synthesis in spleen ...