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Analysis of DNA damage induced by aflatoxin B1 in Dunkin-Hartley guinea pigs
Aflatoxin B1 (AFB1) is among the most potent naturally occurring carcinogens and classified as a group I carcinogen. Since the ingestion of aflatoxin-contaminated food is associated with several liver diseases, the aim of ...
What's the signification of nuclear vacuoles in human sperm?
The aim of this study was to determine the extent of DNA fragmentation and the presence of single/denatured or double stranded of DNA in sperm with large nuclear vacuoles (LNV) selected by high-magnification. A total of ...
The role of mitochondrial DNA damage in the citotoxicity of reactive oxygen species
(SPRINGER/PLENUM PUBLISHERS, 2011)
Mitochondria contain their own genome, a small circular molecule of around 16.5 kbases. The mitochondrial DNA (mtDNA) encodes for only 13 polypeptides, but its integrity is essential for mitochondrial function, as all 13 ...
Relationship between DNA damage and sperm head birefringence
(Elsevier B.V., 2011-06-01)
Birefringence or double refraction is the decomposition of a ray of light into two rays when it passes through an anisotropic material such as quartz. Sperm cells have been demonstrated to be optically anisotropic. The ...
Relationships between cagA, vacA, and iceA genotypes of Helicobacter pylori and DNA damage in the gastric mucosa
Helicobacter pylori (H. pylori) is believed to dispose carriers to gastric cancer by inducing chronic inflammation. The inflammatory processes may result in the generation of reactive oxygen and nitrogen species that damage ...
DNA damage in wistar kyoto rats exercised during pregnancy
Purpose: To evaluate DNA damage levels in pregnant rats undergoing a treadmill exercise program. Methods: Wistar Kyoto rats were allocated into two groups (n= 5 animals/group): non-exercise and exercise. The pregnant rats ...
DNA damage and nitric oxide production in mice following infection with L. chagasi
(Elsevier B.V., 2011-08-16)
Leishmania chagasi, which causes visceral leishmaniasis in South America, is an obligate intracellular protozoan. Production of nitric oxide by macrophages during the inflammatory response is one of the main microbicidal ...
Lymphocyte DNA damage correlates with DNA damage in lung tissue determined by single cell gel electrophoresis
(Federation Amer Soc Exp Biol, 2011-04-01)
DNA damage and repair in leukocytes of melanoma patients exposed in vitro to cisplatin
(LIPPINCOTT WILLIAMS & WILKINS, 2011)
Resistance to chemotherapeutic drugs can be an obstacle to a successful treatment of cancer patients in part associated with individual response and differences in the DNA repair system. The Comet assay is an informative ...