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Predicting the effect of disordered linkers on effective concentrations and avidity with the “Ceff calculator” app
(Elsevier Academic Press Inc., 2021-01)
Linkers are crucial to the functions of multidomain proteins as they couple functional units to encode regulation such as auto-inhibition, enzyme targeting or tuning of interaction strength. A linker changes reactions from ...
Intrinsically disordered linkers impart processivity on enzymes by spatial confinement of binding domains
(Multidisciplinary Digital Publishing Institute, 2019-05)
(1) Background: Processivity is common among enzymes and mechanochemical motors that synthesize, degrade, modify or move along polymeric substrates, such as DNA, RNA, polysaccharides or proteins. Processive enzymes can ...
Two polymeric nickel(II) complexes with aromatic benzene-1,2,4,5-tetracarboxylate and pyridine-2,5-dicarboxylate linkers
(WILEY-BLACKWELL PUBLISHING, 2009-07)
mu-Benzene-1,2,4,5-tetracarboxylato-kappa O-2(1):O-4) bis[aquabis(2,2-methylpropane-1,3-diamine-kappa N-2,N') nickel(II)] methanol disolvate tetrahydrate, [Ni-2(C10H2O8)(C5H14N2)(4)(H2O)(2)]center dot 2CH(4)O center dot ...
Is there nascent structure in the intrinsically disordered region of troponin I?
(Wiley-blackwellMaldenEUA, 2011)
Modelagem por homologia e dinâmica molecular da estrutura selvagem completa de E6 de HPV 16
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2009)
Cervix cancer is a worldwide problem, increasingly affecting women all over the globe which could lead to high mortality rates when not diagnosed in early stages. Virtually all cervical cancers has Human Papillomavirus ...
Modelagem por homologia e dinâmica molecular da estrutura selvagem completa de E6 de HPV 16
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2009)
Cervix cancer is a worldwide problem, increasingly affecting women all over the globe which could lead to high mortality rates when not diagnosed in early stages. Virtually all cervical cancers has Human Papillomavirus ...
Synthesis and cholinesterase inhibition of cativic acid derivatives
(Elsevier, 2014-06)
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with memory impairment and cognitive deficit. Most of the drugs currently available for the treatment of AD are acetylcholinesterase (AChE) inhibitors. ...