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Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain
(Elsevier Ireland, 2017-11)
Aging is associated with a progressive increase in the incidence of neurodegenerative diseases, with Alzheimer's (AD) and Parkinson's (PD) disease being the most conspicuous examples. Within this context, the absence of ...
Reprogramação de astrócitos corticais em neurônios utilizando coquetel de pequenas moléculas
(Universidade Federal do Rio Grande do NorteBrasilUFRNBiomedicina, 2016-11-02)
Recently, many techniques have been described to generate neurons that could be used in cell-based therapies to neurodegenerative diseases or acute central nervous system injuries. One of such techniques is the lineage ...
Regenerative Medicine for the Aging Brain
(Enliven, 2014-12)
In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the basal forebrain cholinergic system is known to undergo moderate ...